Sentinel vs. Trifexis: Which all-in-one preventive is best for your pet?

Which heartworm preventative is right for your dog?

If you’re like most pet owners, you want to provide your pet with the best protection from parasites with the least risk, hassle (for you and your pet), and cost. To help you decide which all-in-one preventive is best for you, we’ve put together a comparison of two major all-in-ones: Sentinel and Trifexis.

Similarities between Sentinel and Trifexis

Both Sentinel and Trifexis:

  • Contain the active ingredient Milbemycin Oxime, so they both treat and control roundworms, hookworms, and whipworms and protect against heartworms
  • Are chewable tablets that should be given once a month
  • Require a prescription from your veterinarian
  • Can be purchased online at 1-800-PetMeds

Differences between Sentinel and Trifexis

  • Cost
    One dose of Sentinel costs about $5 less than one dose of Trifexis.
  • Age at which each can be administered
    Sentinel can be given to puppies at beginning at 4 weeks; Trifexis can be given to puppies beginning at 8 weeks.
  • Minimum weight requirements
    Sentinel can be given to dogs as small as 2 pounds; Trifexis can be given to dogs as small as 5 pounds.
  • Flea control properties
    Sentinel contains Lufenuron, which prevents flea egg development and ends the flea life cycle, but doesn’t kill adult fleas; Trifexis contains Spinosad, which kills fleas (it has been proven to kill 100% of all biting fleas within four hours).
  • Cautions
    You should be cautious when giving any medication to your pet. And make sure you mention any other prescription medications or supplements you’ve given your pet to your veterinarian so he or she can check for drug interactions. Both have the potential for drug interactions. Trifexis carries the following caution: “Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets.”
  • Side effects
    With Sentinel, side effects are rare, but they can occur and may include vomiting; Trifexis may cause vomiting, and other side effects are less likely but possible.
  • Customer reviews
    Sentinel has a 4.4-star rating average from online shoppers and Trifexis has a 3.7-star rating average from customers.

We hope that this comparison has helped you decide which all-in-one preventive is right for you. Once you’ve decided, we hope you’ll visit 1-800-PetMeds for all of your pet supplies. Happy shopping!

Update 11/13/2013:  According to the FDA and Eli Lilly, Trifexis is safe and effective when used according to label instructions.  Unfortunately a small percentage of dogs may experience adverse reactions when taking this or any medication.  We encourage pet owners to consult their veterinarian before administering Trifexis or any other medication to their pets.

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