Sentinel vs. Trifexis: Which All-in-One Preventive Is Best for Your Pet?

Which heartworm preventative is right for your dog?

If you’re like most pet owners, you want to provide your pet with the best protection from parasites with the least risk, hassle (for you and your pet), and cost. To help you decide which all-in-one preventive is best for you, we’ve put together a comparison of two major all-in-ones: Sentinel and Trifexis.

Similarities between Sentinel and Trifexis

Both Sentinel and Trifexis:

  • Contain the active ingredient Milbemycin Oxime, so they both treat and control roundworms, hookworms, and whipworms and protect against heartworms
  • Are chewable tablets that should be given once a month
  • Require a prescription from your veterinarian
  • Can be purchased online at 1-800-PetMeds

Differences between Sentinel and Trifexis

  • Cost
    One dose of Sentinel costs about $5 less than one dose of Trifexis.
  • Age at which each can be administered
    Sentinel can be given to puppies at beginning at 4 weeks; Trifexis can be given to puppies beginning at 8 weeks.
  • Minimum weight requirements
    Sentinel can be given to dogs as small as 2 pounds; Trifexis can be given to dogs as small as 5 pounds.
  • Flea control properties
    Sentinel contains Lufenuron, which prevents flea egg development and ends the flea life cycle, but doesn’t kill adult fleas; Trifexis contains Spinosad, which kills fleas (it has been proven to kill 100% of all biting fleas within four hours).
  • Cautions
    You should be cautious when giving any medication to your pet. And make sure you mention any other prescription medications or supplements you’ve given your pet to your veterinarian so he or she can check for drug interactions. Both have the potential for drug interactions. Trifexis carries the following caution: “Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets.”
  • Side effects
    With Sentinel, side effects are rare, but they can occur and may include vomiting; Trifexis may cause vomiting, and other side effects are less likely but possible.
  • Customer reviews
    Sentinel has a 4.4-star rating average from online shoppers and Trifexis has a 3.7-star rating average from customers.

We hope that this comparison has helped you decide which all-in-one preventive is right for you. Once you’ve decided, we hope you’ll visit 1-800-PetMeds for all of your pet supplies. Happy shopping!

Update 11/13/2013:  According to the FDA and Eli Lilly, Trifexis is safe and effective when used according to label instructions.  Unfortunately a small percentage of dogs may experience adverse reactions when taking this or any medication.  We encourage pet owners to consult their veterinarian before administering Trifexis or any other medication to their pets.

Related Posts


  1. Gave It to my healthy 7 mo old Rhodesian Ridgeback dog. In under 2 hours later he was dead. I was told there was most likely an underlying condition. So we had a licensed pathologist perform a necropsy and guess what? There was no underlying condition. To quote the report directly.
    “We can confirm that there were no preexisting conditions that could be detected either grossly
    or microscopically.”
    All I know is this was my experience. My dog was fine he took the medication and then he died. They can’t find any cause so draw your own conclusion

    • Hi Sarah,

      I’m so sorry for your loss! The loss of a pet is hard enough, but to lose one so young and suddenly is tragic. Just for clarification, can you please let me know which medication gave your dog – Sentinel or Trifexis?

      Warm Regards,

    • Which did you use?

    • I am so sorry for your loss, Sarah! Please advise which medication did you use? I’ve been using Sentinel on both of my dogs for a few years now, I was just about to try Trifexis when I saw this post.

  2. I’m sorry you lost your dog, but you need to be specific and name the product when you’re making allegations about it killing your dog. This article is comparing 2 different products so we don’t know which one you used. I recently read some negative things about Trifexis that could be in line with what happened to you, but I’ve been using it for my dogs for years and never had a problem.

  3. I have used Trifexis on my shelties for six years with no problems. Was just wondering if Sentinel works just as well at a lower price. It looks like the flea control might be a problem with Sentinel, if it doesn’t actually kill adult fleas. Can anyone out there make a comparison from experience?

    • I put my dog on Sentinel 4years ago and she got fleas . So I switched her to Trifexis. No fleas since. While she hasn’t seemed to have any problems on Trifexis, all these stories I read and hear about scare me. If you do go with Trifexis make sure to talk to your vet first. But honestly if Sentinel has worked for you for 6 years why not just stick with that one?

  4. I use Trifexis, no problems so far. I have a 6 month old Standard Schnauzer and he’s used it twice so far. I do believe he vomited the second time, but not sure because I made the mistake of giving it to him before I left for work. As well he had apple pieces for the second time that day, so I’m not sure which caused the apple upchuck. Like everyone else, I am curious about which of the 2 meds the Rhodesian was using before his tragic demise.

  5. Trifexis and Sentinel are now owned by the same company, Eli Lilly. Novartis who was the original manufacture of “Sentinel” (a heartwarm drug with a much safer track record than Trifexis) had their Animal Health business bought out by Eli Lilly (the manufacture of Trifexis) and Company for approximately USD 5.4 billion in Jan 2015. (Source:

    A formal complaint was made to the FTC:

    FDA review on Trifexis can be found here:!documentDetail;D=FDA-2011-N-0003-0005

  6. I have two healthy dogs and used the Trifexis which never caused negative side effects to my knowledge. I switched to Sentinel because it seemed like a better deal. Boy, was I wrong. Both dogs immediately got flees, and I had to spend extra money on grooming and a messy, stinky topical flea treatment (Frontline). (Don’t worry I got consulted with my vet). The Spinosad makes Trifexis worth it, though it is still outrageously expensive. I hope there is a generic soon.

    • Is there a generic Trifexis? I spent about $20 per trifexis pill with our mobile vet. Or does anyone know where I can find it cheaper.

  7. I have a MDR1 Australian shepherd who had a toxic reaction to Trifexis (seizures); we changed to Sentinel and he was fine. The next year (2016) he went blind after the second dosage. My heart is broke. So much for being a good mom.

  8. So very sorry for all whose kids had a reaction, and thank you for posting. My poor boxer terrier girl who has manageable food allergies and ivermectin toxicity was taken off Sentinel which had been an effective and event free treatment for a year by her new vet. New vet was informed repeatedly about that.
    She got hives , swollen feet and muzzle, a few days after her first dose. She started out going off her food, then her skin erupted and she was itching terribly, couldn’t even sleep. Seems to be easing now beginning week 3. Will have to change vets again if we can’t get Sentinel. There is a reason it can be given to 4 week old puppies.

  9. I found this site totally out of frustration. My small dog falls for anything disguised as a “Snack”, so she’s easy to medicate. However I have a 75 lb Lab also …., He does not think their a “Delicious flavored Chew”, in fact he gives me the, you eat that thing look. If I smash it up and put in his meal or snack, he won’t eat it. Trust me this beast doesn’t pass on food. It’s Ginormous, in order to accommodate his weight. Forcing a pill that size on him Is like wrestling a Bear !! No cheese won’t trick him either. I spent a pile of $$ on them, and they are super effective. I’m just wanting to not give him to the Circus every month. GEEEEZZZ !!!

    • Amy sorry just saw the reply button after I posted. look down for my post from Donna G. I went through the same thing till I found the trick ! Good luck

  10. My pit bulls were on Sentinel last year (they were 1.5 years old at the time), and they did great. No reactions, no buggies, no problems.

    After reading about other dogs’ side effects and long term health problems, I became weary of conventional preventatives. I did some research and saw that a lot of people swore by natural remedies. Of course it sounded promising and the overall the best option being it was natural, had no side effects, no long term health problems, and being more cost efficient. (Apple cider vinegar, brewer’s yeast, diatomaceous earth, probiotics, etc)

    Of course, there’s that age old saying “if it sounds too good to be true, then it probably is.

    I was consistent, patient, and relentlessly hopeful. But after 3 months, my dogs had fleas (never had fleas on Sentinel) and intestinal worms (never had worms on Sentinel). Granted, they spent a lot of time around our roommates untreated cat. She went in/out of the house very often. This may or may not have been a contributing factor to the natural remedies not working. I like to believe it was, because natural medicine has always yielded great results for my human ailments.

    Anyway, I put them back on Sentinel while continuing their natural remedies. Our roommate recently got a dog who is not on preventatives. Our dogs, however, do not seem to be affected as of currently (it has been 1 month). This leads me to believe in the efficacy of Sentinel (plus the powers of natural medicine).

  11. I just sitting dog for friends , dog sleep 24 7 constantly , lethargic , I never ever see horrible drug out dog , poor dog id on Sentinel and Corthofen.
    He is drug out completely . Please people stop drug out your DOG’S. I am devastated, USE NATURAL STUFF, LOOK ON INTERNET . DOG’S SUFFERING TERRIBLE FROM HORRIBLE INTERNALS SIDE EFFECTS

  12. This is for Amy H or anyone having a problem getting their dog to take trifexis. I have learned if you go to your local health food store you can buy large size gel capsules. I crush the trifexis and fill them,yes it does take a few of them and I really have to pack both sides. My boxer Brady gets boiled boneless skinless chicken breast in his food so I take some of it and blend it into chicken paste and coat them!!! My vet said that is fine to do and it works.He has had two cancer surgerys and this is the only way we can get him to take any pain meds ect. I also will put the coated capsule in one hand and just a ball of chicken paste in the other, as soon as I give him the capsule I offer the ball of paste and down goes the capsule. being sneaky is the trick.

Leave a Comment