Denamarin: Liver Support for Pets

Filed under Dr. Dym's Vet Blog
From one of the most trustworthy nutritional supplement companies on the market, Denamarin is an excellent multifaceted supplements that can significantly improve liver function by increasing liver glutathione levels. The duel main ingredients of SAMe and Silybin (active ingredient of milk thistle) are potent antioxidants that protect liver cells and may even promote liver cell regeneration in dogs with active liver disease.

The product also can help with digestion and absorption of nutrients from the diet as well. There are no negative side effects seen with this product, and on the positive side, pets usually become more active and playful as liver function improves when taking this product.

Increased activity levels are often a noticeable benefit when pets are given Denamarin

It is certainly safe to use long term and even as a preventative in those pets who are also taking medications that may be toxic to the liver such as prescription nonsteroidal anti-inflammatory medications such as Rimadyl, Deramaxx, Previcox or Metacam. The only client concerns I have seen with this product revolve around the cost. However, because of the combination of wonderful synergistic liver supportive ingredients in this one product, it is certainly highly worth it in my opinion and experience.


  1. Nancy
    Posted August 13, 2011 at 11:46 am | Permalink

    Is there a generic product available for Denamarin due to the high cost?

  2. Dr. Michael Dym, VMD veterinarian
    Posted August 14, 2011 at 10:43 pm | Permalink

    You can try SAMe from health food store along with milk thistle as well which would be equivalent to buying the denamarin, however SAMe can get expensive as well.

  3. Posted December 21, 2011 at 4:51 pm | Permalink

    is denamarin still effective with food…it was recommended to take on an empty stomach but i have a very hard time getting it in my dog

  4. Dr. Michael Dym, VMD veterinarian
    Posted December 21, 2011 at 4:54 pm | Permalink

    Giving it with food should not be a problem.

  5. Natalie
    Posted December 27, 2011 at 2:11 pm | Permalink

    What about the generic version of the pill? S-Adenosyl 100MG. I assume there are no problems with the generic? It does not seem to be available on petmeds yet, but I have found it on other websites.

  6. Dr. Michael Dym, VMD veterinarian
    Posted December 28, 2011 at 2:28 pm | Permalink

    The generic version should be fine for liver support.

  7. Sharon
    Posted April 22, 2012 at 5:18 pm | Permalink

    How many mg. of Milk Thistle?

  8. Dr. Michael Dym, VMD veterinarian
    Posted April 22, 2012 at 9:10 pm | Permalink

    50-100 mg is typical dose daily.

  9. CAROL
    Posted May 30, 2014 at 6:57 pm | Permalink

    I was also told by my vet to only give Denamarin without food. I tried for 15 minutes and got one pill down and in trying the second one my dog would not let me and I almost got bitten because he would not let me open his mouth. I do understand that it works better on an empty stomache, but a pill with a tiny bit of food should be better than none at all?

  10. Dr. Michael Dym, VMD veterinarian
    Posted June 2, 2014 at 6:06 pm | Permalink

    I dont find giving this supplement with a bit of food a problem

  11. Jay
    Posted October 8, 2014 at 10:34 am | Permalink

    I am curious about using this on a dog with Hepatocellular Carcinoma. My dog had a very large (5.5 lbs) grade 2 HCC removed 2 years ago. She has been doing very well in these last two years. However, we did a CBC and abdominal ultrasound recently, in preparation to remove a Grade 3 Mast Cell Tumor from her ear, and discovered she had slightly elevated liver enzymes. Aspirates from a small mass on her liver–in the area where remnants from her liver lobectomy was done–indicate a probable return of the HCC. If Denamarin is protective against liver cell death, am I giving the cancer cells a boost at the same time I am helping her healthier liver cells? Has any research been done? I am not too worried about the HCC on its own, as it is small at this time, slow growing, and my dog is already 13 years old (though you would never know it to look at and hang out with her!). I like the positive impact of Denamarin, but I don’t want to encourage the HCC to thrive either. Any insights would be appreciated.

  12. Dr. Michael Dym, VMD veterinarian
    Posted October 9, 2014 at 3:58 am | Permalink

    I dont think the main ingredients in the denamarin would affect the tumor in a negative way as the two main ingredients milk thistle and SAMe are both antioxidants and liver cell protectants for the general organ. There are no contraindications with this product as far as I know from a promoting cancer perspective. You also may want to consult with a holistic veterinarian as well on other supportive holistic care that may help her at this age, rather than putting her through more surgery and/or chemo/radiation, etc

  13. Jay
    Posted October 9, 2014 at 10:23 am | Permalink

    Thank you so much for the reply. I WOULD like to follow up with a holistic practitioner, as I am currently really struggling with the decision making process as far as the MCT goes. We have recommendations for a second, more aggressive surgery on her ear, with a probable full ablation being the result, followed by ‘lifetime’ treatment with Palladia. It sounds like a lot. She is a vibrant and active 13 year old–for all appearances, half her age–butt still, she is 13, and I don’t want to overwhelm her. She has bounced back from her previous surgeries beautifully…the removal of the HCC at the age of 11, and the partial ear removal from the MCT just about a month ago. But I hate to keep putting her through it. I will see if I can find a good holistic practitioner to consult with. We already use a lot of nutritional and supplemental support–K9 Immunity, home cooking, and just started with the Denamarin. I just wish the MCT wasn’t such a scary and unpredictable cancer.

  14. Dr. Michael Dym, VMD veterinarian
    Posted October 10, 2014 at 5:10 pm | Permalink

    Palladia is an excellent drug but certainly very expensive costing hundreds of dollars a month. A holistic consultation certainly would be a good option

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