Drug Interactions with Pet meds

Drug interactions can also occur in pet medications, which is why you should always let your vet know of any other pet meds your pet is on

One of the most overlooked topics in veterinary medicine surrounds the issue of drug interactions and the side effects of medication. In the middle of a busy veterinary practice, many veterinarians often fail to take the time to discuss these possibilities. For example, many commonly prescribed nonsteroidal anti-inflammatory medications (NSAIDs) can sometimes cause digestive upset and/or liver/kidney problems in some sensitive pets. Corticosteroids like Prednisone can cause similar problems in some pets, as well as predispose pets to diabetes with prolonged use.

While a topic of debate, these risks are increased if Prednisone and nonsteroidal anti-inflammatory drugs are used together.  While potentially life saving, antibiotics can also cause allergic reactions from digestive upset to skin eruptions. Some pets are sensitive to topical flea and tick medications, and in my practice I always use flea and tick medication on a separate day from heartworm preventative medication administration or vaccinations, in order to lessen the burden on a pet’s immune system.

Whenever multiple drugs are prescribed it is always important for clients to ask questions and/or veterinarians to make them aware of these issues, as veterinarians not only prescribe medication but are also dispensing medications in private practice much like pharmacists do for humans and at 1800PetMeds.

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1,479 Comments

  1. Can I give Rilexine and temaril at the same time to my boxer because he has hair loss and won’t stop itching with the temaril causing sores on his belly?

  2. My 12 year old Boston has diabetes and is blind. He takes 23 units of insulin twice a day and gets eyedrops for glaucoma. He also has a heart condition. He takes proin, enalapril, and thyophylline. He is very restless at night. Can’t seem to lie down and pants a lot. Would it be OK to give him diazapam before bed while taking all these other drugs? Thank you.

    • Dr. Michael Dym, VMD veterinarianMarch 18, 2015 at 1:38 pm · Reply

      PRobably ok to use diazepam, however this should be done under care and recommendation of your veterinarian. You could also consider natural calming agent like L-theanine from health food store at dose of 3 to 500 mg twice daily

  3. I have a six year male chi, he is on prednisone 1 mg a day, for Addison’s disease. Can he take 1/2 of temaril-p, with the prednisone? He has a respitory infection that is making him cough. So can he take these two pills together?
    Thank you Deanne Vargas

    • Dr. Michael Dym, VMD veterinarianMarch 18, 2015 at 1:11 pm · Reply

      I dont think this would be a problem, however should be done under care and monitoring of your veterinarian

  4. My dog takes Pepcid 1/2 twice a day, and sometimes benadryl at night, can she take the Anxitane by Virbac, calming pill with these? And can this calming pill be taken long term? SHE IS 7 year old 14 lb Schipperke, very nervous type dog.

    • Dr. Michael Dym, VMD veterinarianMarch 18, 2015 at 1:09 pm · Reply

      No problem in adding anxitane to your regimen and/or using this product long term. May be more economical to get L-theanine in health food store, more cheaply, as that is main ingredient in this product. Also you can use WIDE dose range of this product up to 500 mg of L theanine

  5. My cat’s been been prescribed Albon, and I would like to know if there is any contraindication for giving him Cerenia at the same time…

    Thanks in advance!
    ~Les.

  6. My dog was neutered Friday. Had him to vet today . wanted to know if I can give him Benadryl with carprofen 25 mg and cephalexin 250 mg.. He is in a lot of pain. If so how much should I give him His weight is 17 lbs.

    • Dr. Michael Dym, VMD veterinarianMarch 18, 2015 at 12:32 pm · Reply

      Dose would be a children’s benadryl up to twice daily. See vet if signs persist or worsen.

  7. my cat has diaerrhea and an ear infection can I give him metrometazole and clavaseptin at the same time

  8. My pharmacist says that I should not give my cat famotidine and metronidazole at the same time. I would like to know the mechanism of why they interact and why it makes my cat feel more sick than before medication. Thank you in advance.

  9. I have an almost 7 yr old wire haired dachshunds that has really bad allergies. He is on Temaril P and my vet prescribed him Previcox for arthritic pain. I gave him one Previcox and a couple days later the Temaril P. Should this be ok for my dog? He seems to be acting fine but I didn’t know if there would be any reactions that I should be aware of. Thanks!!!

  10. Hi
    My 30kg dog is on 0.7mg of Soloxine daily is it ok to give 5-HTP or L Theanine to assist with his fears and stress levels?
    Many Thanks

  11. i have a healthy 86 # dog with laceration on toe that required stitches and staples. It’s healing well but at this point the bandage is off and he is supposed to keep off his foot as much as possible for the next few days. I have acepromizine, but benadryl works just as well and my vet said is safer. problem is both only sedate him for about 4 hours. I think I can only give it q 8 h. what to do? he is extremely active when unsedated.

  12. i have a 13.5 yr old black lab. She has glaucoma in her right eye. Is it safe to give left over Ultram for discomfort related to the glaucoma? Any contraindications using it with glaucoma?

  13. Is it okay to use dlpa along with clavamox? Thanks.

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