Why you need to ask your vet about pet drug interactions & side effects

Discuss potential medication side effects with your vet

In the middle of a busy veterinary practice, many veterinarians may overlook an opportunity to discuss the possibilities of drug interactions and pet medication side effects. For example, many commonly prescribed nonsteroidal anti-inflammatory medications (NSAIDs) can sometimes cause digestive upset and/or liver/kidney problems in some sensitive pets. Corticosteroids like Prednisone can cause similar problems in some pets, as well as predispose pets to diabetes with prolonged use.

While a topic of debate, these risks are increased if Prednisone and nonsteroidal anti-inflammatory drugs are used together.

While potentially lifesaving, antibiotics can also cause allergic reactions from digestive upset to skin irritation. Some pets are sensitive to topical flea and tick medications, and in my practice I always administer topical flea and tick medication on a separate day from heartworm preventative medication or vaccinations, in order to lessen the burden on a pet’s immune system.

Whenever multiple drugs are prescribed it is always important for pet owners to ask questions, because veterinarians not only prescribe pet medication but are also dispensing these medications in private practice.

Do you have a question on potential pet medication interactions or side effects? Leave a comment below. 

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1,624 Comments

  1. Is it safe to give prednisone and mometamax at the same time?

  2. My 8lb Yorkie, 10 years, had dental surgery 48 hrs ago (9 teeth removed). Can he have his Comfortis flea pill, in combination w/ the antibiotic Clavamox and pain med Tramadol?

    • I personally would wait on the comfortis pill a week or two until after he has recuperated from his dental surgery and completed his source medicines post dental. These tiny breeds are sensitive enough to begin with and I would wait until his body has completely recovered from the procedure. I would check, however with your local veterinarian, who knows him best

  3. Can i give my dog benadryl and proin at the same time

    • I personally have not seen an problem with benadryl and proin use at same time, however I would also check with your local vet who has prescribed these, and who knows your pet best

  4. Antirobe and apoquel

    • I have personally not seen any problems when antirobe and apoquel have been prescribed at the same time, however best to check with your local veterinarian, who has prescribed these medications and who knows your pet best

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