Drug Interactions with Pet meds

One of the most overlooked topics in veterinary medicine surrounds the issue of drug interactions and the side effects of medication. In the middle of a busy veterinary practice, many veterinarians often fail to take the time to discuss these possibilities. For example, many commonly prescribed nonsteroidal anti-inflammatory medications (NSAIDs) can sometimes cause digestive upset and/or liver/kidney problems in some sensitive pets. Corticosteroids like Prednisone can cause similar problems in some pets, as well as predispose pets to diabetes with prolonged use.

Drug interactions can also occur in pet medications, which is why you should always let your vet know of any other pet meds your pet is on

While a topic of debate, these risks are increased if Prednisone and nonsteroidal anti-inflammatory drugs are used together.  While potentially life saving, antibiotics can also cause allergic reactions from digestive upset to skin eruptions. Some pets are sensitive to topical flea and tick medications, and in my practice I always use flea and tick medication on a separate day from heartworm preventative medication administration or vaccinations, in order to lessen the burden on a pet’s immune system.

Whenever multiple drugs are prescribed it is always important for clients to ask questions and/or veterinarians to make them aware of these issues, as veterinarians not only prescribe medication but are also dispensing medications in private practice much like pharmacists do for humans and at 1800PetMeds.

Comments

  1. Trina says

    My dog is currently on Doxycycline for upper respiratory complications due to kennel cough. Neither of us are sleeping, would it be ok to give benedryl? I have read that benedryl is fine for dogs, I just don’t know about the combination.

  2. Rob Joyner says

    My 14 year old, 8.63lb, kitty had a sore and swollen throat and the vet gave her Dexamethasone (2mg/ml) and Convenia (7.5-10#) injections a week and a half ago. She is doing much better.
    I have other cats and one’s UPI has flared up, with runny eyes, nose and a lot of sneezing. He’s almost 2 years old. I’ve begun to give him Orbax liquid for the symptoms.
    Question – should I also give the 14 year old Orbax in order to ward off UPI from the other cat? Is Orbax okay to give her since she’s had the mentioned injection medication? Thanks for your time.

  3. Rob Joyner says

    (I’m not sure if my post went through the first time. If it did, my apologies. But just to make sure, here it is again.)

    My 14 year old, 8.63lb, kitty had a sore and swollen throat and the vet gave her Dexamethasone (2mg/ml) and Convenia (7.5-10#) injections a week and a half ago. She is doing much better.
    I have other cats and one’s UPI has flared up, with runny eyes, nose and a lot of sneezing. He’s almost 2 years old. I’ve begun to give him Orbax liquid for the symptoms.
    Question – should I also give the 14 year old Orbax in order to ward off UPI from the other cat? Is Orbax okay to give her since she’s had the mentioned injection medication? Thanks for your time.

    • Dr. Michael Dym, VMD veterinarian says

      The orbax should not be a problem, although I would check with your local vet first who gave the convenia shot.

  4. Joy Ashurst says

    My 17 plus year old cat starting having seizures in Dec. The Vet prescribed Phenobarbital 5mg pill to be cut into quarters and to give her that 1/4 daily. It is nearly impossible to cut the pill evenly. I was aware that some doses are smaller than others but gave that amount anyway. She had her first seizure last night since she became medicated for it. I feel that if smaller doses are given for several days in a row, that could trigger a seizure. How am I to give her the right dose if I have to cut a tiny pill like that. Don’t they have pills for animals?

    • Dr. Michael Dym, VMD veterinarian says

      Contact 1800petmeds pharmacist or another compounding pharmacy like Wedgewood, which you can find on line. They usually compound these type of meds into user friendly liquids.

  5. JB says

    What should be done if you suspect your child could have injested one 50mg trramadol HCI tab prescribed for our dog?

    • Dr. Michael Dym, VMD veterinarian says

      You need to call poison control center and/or go to your local human emergency room if needed.

  6. Kris says

    My 13 lb poodle is on 25 mg Carprofen. They want her to take 1/8 tsp liquid silver supplement. Is it ok to mix these?.

    • Dr. Michael Dym, VMD veterinarian says

      I dont use much liquid silver supplement in my practice, so I cant comment, however I would check with your local vet

  7. Ridge Runner Vet says

    My 7 year old dog is on phenobarbitol 60 mg twice a day. Now she is going to need to be on proin. Are there any worries of mixing these two drugs in this dog?

    • Dr. Michael Dym, VMD veterinarian says

      Usually no problem, in my experience with these two drugs, but I would make sure you were still under the care of a local vet while on these two meds.

  8. Toni says

    I have a 10 yr.old dog with Addisons…percotin every 25 days/prednisolone 5mg daily. Stress is bad for her… has problems with thunder and wind…sometimes I have problems getting her thru it. My vet says no ace….what do you think? Thank-you.

    • Dr. Michael Dym, VMD veterinarian says

      Low dose ace is probably ok, but can lower their blood pressure. Probably safer to ask vet for script for xanax, which is probably much safer. Also natural treatment options worth a try as well, including composure from 1800petmeds, as well as L-theonine from health food store at dose of 2 to 400 mg as needed.

  9. Vicky says

    my vet has my dog 14 lb Schipperke on 1/2 of 10 mg Pepcid twice a day, I read online u should only give a 1/4th tab under 20 lbs..?

  10. Lise H says

    My 4.5 lb papillon is 14 years old and having terrible fainting spells or seizures. The cardiologist is not sure which. She is on pimobendan, salix, and enalapril, and has been prescribed a test low dose of phenobarbital. Do you see any problems with that?

      • Lise says

        Thank you very much. The dosage was reduced to 1/2 a ml once a day because she had bleeding in her stomach or small intestine, and there was just too much going on. I will talk with the vet about gradually getting her off the pheno.

  11. Marcia M. says

    Hi- Last evening my Vet gave my 11 yr. old, 22 lb. dog Previcox 57mg. to take once a day because she won’t put weight on one of
    her hind legs. The receptionist forgot to give any
    instructions and they are out until Mon. She is on Enalapril 5mg. a day and I read that it can interact with the Previcox.
    Not sure what to do? Any advice would be appreciated.
    Thank you.

  12. Katy says

    my 47lb, 2yr old dog is taking two doses of 50mg hydoxizine HCL a day for an allergic reaction. can she still receive her dose of advantage multi (topical) that is due?

  13. Connie Chichester says

    My 3yoa female 12lb shelti-doodle (& Chihuahua) has been on monthly meds of Nexgard & Heartgard, may I without cause for one or two months give her Sentinel & Heartgard? I helped a stray & now we’re short but I have two Sentinel tabs left from recently. Thanks so very much, just wanting to remain cautious.

  14. DeAnna Hudson says

    Hi,
    I gave my Chihuahua who has been on crate rest for a back injury the last 12 weeks 1 teaspoon of Benadryl 9 hours ago for allergies. He’s prescribed acepromazine to take at night to help him rest. Is it okay to give him at 9 p.m. twelve hours after the Benadryl?

  15. sheria says

    My dog is breaking out in hives from an allergic reaction to something, the vet gave me relexine, it is not helping and her reaction is getting worse, can I give her a little bit of Benadryl while she’s on the relexine? I want to be completely safe. Thank you.

  16. Connie Chichester says

    Hey guys gals, I don’t wish to be ungrateful, mean or speak out of turn here; perhaps I’m ignorant and not doing something correctly?

    The thing is, I truly needed a timely response to a medication question for my dog, posted the question, signed up to receive updates regarding the question and have waited a week +/-.

    Going back to your site, one must scroll through countless Q&A’s from 2011 to 2014. I can’t even find my question let alone an answer. There doesn’t appear to be any organization, search capabilities, etc. …

    Thank you for your time and God luck in family and business.
    Connie

  17. Ron Folsom says

    My dog has we believe allergies. He has a bad cough at times. Can I give him benadryl and torbutrol together?

    • Dr. Michael Dym, VMD veterinarian says

      I dont think this combo a problem, but best check with your local vet who is treating him.

  18. Brittany Frank says

    Can I give Rilexine and temaril at the same time to my boxer because he has hair loss and won’t stop itching with the temaril causing sores on his belly?

  19. J Rosenfeld says

    My 12 year old Boston has diabetes and is blind. He takes 23 units of insulin twice a day and gets eyedrops for glaucoma. He also has a heart condition. He takes proin, enalapril, and thyophylline. He is very restless at night. Can’t seem to lie down and pants a lot. Would it be OK to give him diazapam before bed while taking all these other drugs? Thank you.

    • Dr. Michael Dym, VMD veterinarian says

      PRobably ok to use diazepam, however this should be done under care and recommendation of your veterinarian. You could also consider natural calming agent like L-theanine from health food store at dose of 3 to 500 mg twice daily

  20. says

    I have a six year male chi, he is on prednisone 1 mg a day, for Addison’s disease. Can he take 1/2 of temaril-p, with the prednisone? He has a respitory infection that is making him cough. So can he take these two pills together?
    Thank you Deanne Vargas

    • Dr. Michael Dym, VMD veterinarian says

      I dont think this would be a problem, however should be done under care and monitoring of your veterinarian

  21. Vicky says

    My dog takes Pepcid 1/2 twice a day, and sometimes benadryl at night, can she take the Anxitane by Virbac, calming pill with these? And can this calming pill be taken long term? SHE IS 7 year old 14 lb Schipperke, very nervous type dog.

    • Dr. Michael Dym, VMD veterinarian says

      No problem in adding anxitane to your regimen and/or using this product long term. May be more economical to get L-theanine in health food store, more cheaply, as that is main ingredient in this product. Also you can use WIDE dose range of this product up to 500 mg of L theanine

  22. Les says

    My cat’s been been prescribed Albon, and I would like to know if there is any contraindication for giving him Cerenia at the same time…

    Thanks in advance!
    ~Les.

  23. Donna says

    My dog was neutered Friday. Had him to vet today . wanted to know if I can give him Benadryl with carprofen 25 mg and cephalexin 250 mg.. He is in a lot of pain. If so how much should I give him His weight is 17 lbs.

    • Dr. Michael Dym, VMD veterinarian says

      Dose would be a children’s benadryl up to twice daily. See vet if signs persist or worsen.

  24. Mitch says

    My pharmacist says that I should not give my cat famotidine and metronidazole at the same time. I would like to know the mechanism of why they interact and why it makes my cat feel more sick than before medication. Thank you in advance.

  25. Candice Forza says

    I have an almost 7 yr old wire haired dachshunds that has really bad allergies. He is on Temaril P and my vet prescribed him Previcox for arthritic pain. I gave him one Previcox and a couple days later the Temaril P. Should this be ok for my dog? He seems to be acting fine but I didn’t know if there would be any reactions that I should be aware of. Thanks!!!

  26. Tina Woods says

    Hi
    My 30kg dog is on 0.7mg of Soloxine daily is it ok to give 5-HTP or L Theanine to assist with his fears and stress levels?
    Many Thanks

  27. anne says

    i have a healthy 86 # dog with laceration on toe that required stitches and staples. It’s healing well but at this point the bandage is off and he is supposed to keep off his foot as much as possible for the next few days. I have acepromizine, but benadryl works just as well and my vet said is safer. problem is both only sedate him for about 4 hours. I think I can only give it q 8 h. what to do? he is extremely active when unsedated.

  28. Dr. Michael Dym, VMD veterinarian says

    Sometimes glucosamine type products can interact with non steroidal anti inflammatory medications so best to be under local vet care. Both type of meds/supplements may thin the blood in some animals, occasionally predisposing to bleeding. Max dose I use for tramadol in my practice is 2 to 2.5 mg per pound twice to three times daily.

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