Drug Interactions with Pet meds

Drug interactions can also occur in pet medications, which is why you should always let your vet know of any other pet meds your pet is on

One of the most overlooked topics in veterinary medicine surrounds the issue of drug interactions and the side effects of medication. In the middle of a busy veterinary practice, many veterinarians often fail to take the time to discuss these possibilities. For example, many commonly prescribed nonsteroidal anti-inflammatory medications (NSAIDs) can sometimes cause digestive upset and/or liver/kidney problems in some sensitive pets. Corticosteroids like Prednisone can cause similar problems in some pets, as well as predispose pets to diabetes with prolonged use.

While a topic of debate, these risks are increased if Prednisone and nonsteroidal anti-inflammatory drugs are used together.¬†¬†While potentially life saving, antibiotics can also cause allergic reactions from digestive upset to skin eruptions. Some pets are sensitive to topical flea and tick medications, and in my practice I always use flea and tick medication on a separate day from heartworm preventative medication administration or vaccinations, in order to lessen the burden on a pet’s immune system.

Whenever multiple drugs are prescribed it is always important for clients to ask questions and/or veterinarians to make them aware of these issues, as veterinarians not only prescribe medication but are also dispensing medications in private practice much like pharmacists do for humans and at 1800PetMeds.

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1,496 Comments

  1. Can I give Rilexine and temaril at the same time to my boxer because he has hair loss and won’t stop itching with the temaril causing sores on his belly?

  2. My 12 year old Boston has diabetes and is blind. He takes 23 units of insulin twice a day and gets eyedrops for glaucoma. He also has a heart condition. He takes proin, enalapril, and thyophylline. He is very restless at night. Can’t seem to lie down and pants a lot. Would it be OK to give him diazapam before bed while taking all these other drugs? Thank you.

    • Dr. Michael Dym, VMD veterinarianMarch 18, 2015 at 1:38 pm · Reply

      PRobably ok to use diazepam, however this should be done under care and recommendation of your veterinarian. You could also consider natural calming agent like L-theanine from health food store at dose of 3 to 500 mg twice daily

  3. I have a six year male chi, he is on prednisone 1 mg a day, for Addison’s disease. Can he take 1/2 of temaril-p, with the prednisone? He has a respitory infection that is making him cough. So can he take these two pills together?
    Thank you Deanne Vargas

    • Dr. Michael Dym, VMD veterinarianMarch 18, 2015 at 1:11 pm · Reply

      I dont think this would be a problem, however should be done under care and monitoring of your veterinarian

  4. My dog takes Pepcid 1/2 twice a day, and sometimes benadryl at night, can she take the Anxitane by Virbac, calming pill with these? And can this calming pill be taken long term? SHE IS 7 year old 14 lb Schipperke, very nervous type dog.

    • Dr. Michael Dym, VMD veterinarianMarch 18, 2015 at 1:09 pm · Reply

      No problem in adding anxitane to your regimen and/or using this product long term. May be more economical to get L-theanine in health food store, more cheaply, as that is main ingredient in this product. Also you can use WIDE dose range of this product up to 500 mg of L theanine

  5. My cat’s been been prescribed Albon, and I would like to know if there is any contraindication for giving him Cerenia at the same time…

    Thanks in advance!
    ~Les.

  6. My dog was neutered Friday. Had him to vet today . wanted to know if I can give him Benadryl with carprofen 25 mg and cephalexin 250 mg.. He is in a lot of pain. If so how much should I give him His weight is 17 lbs.

    • Dr. Michael Dym, VMD veterinarianMarch 18, 2015 at 12:32 pm · Reply

      Dose would be a children’s benadryl up to twice daily. See vet if signs persist or worsen.

  7. my cat has diaerrhea and an ear infection can I give him metrometazole and clavaseptin at the same time

  8. My pharmacist says that I should not give my cat famotidine and metronidazole at the same time. I would like to know the mechanism of why they interact and why it makes my cat feel more sick than before medication. Thank you in advance.

  9. I have an almost 7 yr old wire haired dachshunds that has really bad allergies. He is on Temaril P and my vet prescribed him Previcox for arthritic pain. I gave him one Previcox and a couple days later the Temaril P. Should this be ok for my dog? He seems to be acting fine but I didn’t know if there would be any reactions that I should be aware of. Thanks!!!

  10. Hi
    My 30kg dog is on 0.7mg of Soloxine daily is it ok to give 5-HTP or L Theanine to assist with his fears and stress levels?
    Many Thanks

  11. i have a healthy 86 # dog with laceration on toe that required stitches and staples. It’s healing well but at this point the bandage is off and he is supposed to keep off his foot as much as possible for the next few days. I have acepromizine, but benadryl works just as well and my vet said is safer. problem is both only sedate him for about 4 hours. I think I can only give it q 8 h. what to do? he is extremely active when unsedated.

  12. i have a 13.5 yr old black lab. She has glaucoma in her right eye. Is it safe to give left over Ultram for discomfort related to the glaucoma? Any contraindications using it with glaucoma?

  13. Is it okay to use dlpa along with clavamox? Thanks.

  14. Can prion be taken with thyroid meds? This is for a dog, thanks!

  15. can my dog take glucosamine when she also takes phenobarbital and meloxicam

  16. My American Bulldog has been prescribed Deramax, Cephalexin Soloxine and Temaril p tabs for leg pain, skin infection and possible low thyroid function. she has been on these meds for 6 days. She is panting as if she is really hot and stressed. this has gotten worse over the last couple of days. should I stop any of these meds. I will not give her anything else until I can speak with the vet.

  17. My 13 year old cat is on prednisolone susp and I was curious if she can also take the HomeoPet Digestive Upset? It is an over the counter upset stomach medicine containing Arsenicum Album, Agentum Nitricum, Pulsatilla Nigricans, Hypericum Perforatum, Colocynthis and Veratrum Album.

  18. My 4 year old Lab had Tibial Tuberosity Advancement surgery 2 weeks ago. She takes tramadol, deramaxx, and clavaseptin, as well as weekly cartrophen injections. Her food also has glucosamine and condroitin in it. She had her second injection today and hasn’t been able to hold down any food. The most recent vomit had blood in it. Would it be the cartrophen, or the combination of meds?

  19. I have 11 year old Boston terrier. He was diagnosed with vestibular disease and we are going on day 3. The vet gave us cerenia. Is there anything else like benadryl or prednisone to help? We can’t get him to eat or drink.

  20. My 4 1/2 lb – 7 year old yorkie/Maltese mix is on 2 mg of prednisone twice daily and 5 mg of chlorambucil every third day. She also receives 1cc of B12 once weekly. Is it safe to give her trifecta for fleas?

  21. My dog is taking Apoquel twice a day and baytril once a day. She also on a Royal canin diet with fortiflora and RX clay twice a day with her meals.
    Tonight she is sick. She has been suffering of constant infections to the skin and uterus.

  22. Was given Rimadyl (75 mg) tablets the day prior to dog’s operation and Metacam (15 ml 0.5mg/ml) the day she returned home. Not realizing these two medications were both inflammatory, I didn’t ask questions. The instructions were one tab Rimadyl once per day as needed for pain. On the metacam, I’m to fill the syringe to 30 lbs (she is 30 lbs) and administer by mouth once every 24 hours. Also, was given an antiobiotic (Orbax). I’m not concerned about the antibiotic but am concerned about the double dose of inflammatory drugs. Was this an oversight on the vet’s part or are they meant to be administered on the same day as they possibly work differently to alleviate inflammation? Thanks for any information and your help!

  23. My six year old 68pnd Border Collie/Australian Shepherd mix has develop a terrible red rash on tummy area that seems to be spreading and he’s losing hair. Also has continual ear infections. His body has a yeast/fungal smell and he itches all day and night. Ketoconazole is expensive. What about Prednisone and Cephalexin? He has had a problem in the past with Steriod injection when combined with other shots. I will never mix them again. I know he is miserable

  24. My dog is a 30 lb cocker spaniel. He’s on fluoxetine for separation anxiety and general anxiety. He has a skin infection currently and is on cephalexon, temaril p, and derma-vet ointment. He gets more lethargic than usual a couple hours after having his meds. My vet said there shouldn’t be any sort of reaction with his medications. Is there any way that his fluoxetine and temaril p are reacting with each other?

  25. My 45 pound Boxer got in the box & ate all 6 flea & tick pills (Nexguard). The ASPCA poison number said they’d only talk to a vet. She doesn’t seem distressed (cold nose). Do I need to bring her in to my vet tomorrow or just observe her for problems?

  26. Hi my dog is on Enalapril and Furosemide for CHF and recently was diagnosed with liver stones so the vet added Ursodiol and a “cough tab” which has no other product information on it. He’s not been his usual self since the addition of the Ursodiol and the cough tab. His cough was dry before but is not very fluidy. Not much on the internet to check for drug interactions in pets and our vet says its all good??

  27. My cat takes Gabapentin for Feline Hyperesthesia. Can she also take Zyrtec for her itchiness?

  28. My dog Sally, a Lab/Chow mix, has had skin issue’s her whole Life, She is now ten. Our Vet tried a new drug, which has been a ” miracle”, for Sally , and us. It is called, Apoquel 16 mg. It is not a steroid. We have a NEW Dog !!! We have tried, everything, you name it, she has been on it. Ask your Vet, it has just been approved , about a year. : )

  29. 10.5 year old Staffie with glaucoma now diagnosed with hypothyroidism ( loss of hair on tail and left face parLysis, weak hind end).
    She takes Ester C vitamin c 2xday. She gets Timolol drops 2x day. Now she will take Thyro Tab .4 mg 2x day.
    Any concerns / experiences with any of this??

  30. Should I take my 19yr old Lancashire Heeler to an pet acupuncturer if he not walking or standing? he does have arthritis in right front leg, displaced hip on left, liver and kidney failure (but gets daily fluids – 100 ) had diarrehea for month of December (which is under control now..So he’s been on all types of meds and Hills Prescp Foods, no vomiting, he still wants and likes to eat ,sleeps alot but alert, the Vet seems to have done all they can. I just want to find something that allows him to stand up to eat and walk on his own legs, i have to hold him up, Thank you for any suggestions. BLC

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