EGC or Rodent Ulcers in Cats

Eosinophilic Granuloma Complex (EGC) or rodent ulcers in cats are fairly common presentations in clinical practice. Symptoms may include swelling/ulceration of the lips, which can be sometimes accompanied by drooling and can sometimes affect ability to eat. Some cats will have ulcers present on the gums or tongue as well.

Other presentations of EGC include raised hairless plaques or discrete skin swellings in the abdominal/groin area, as well as areas on the legs.

Eosinophilic Granuloma Complex in cats may cause swelling and ulceration of the lips.

Licking or itching of the affected areas is often present in the history.Causes of this syndrome in cats include flea bite allergies, inhalant/contact allergies and/or food allergies.

I will often try many cats with this syndrome on a restricted novel  protein rabbit or venison protein based diet for 2-3 months to see if food allergies are involved.  Topical flea control with Advantage or Frontline Plus is always recommended in cats with these lesions.  Diagnosis of this syndrome is based on clinical appearance during an office visit, and/or aspiration of the plaques, and microscopic exam of the cells on the microscope.

Treatment may include diet changes, flea control, as well as injectable or oral anti-inflammatory therapy with cortisone to decrease swelling and improve comfort until underlying causes are identified.  Since these lesions sometimes become secondarily infected,  antibiotics are often prescribed as well.

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  1. Ive had my cat to vet twice raked up money and her symtoms come back. I want to get my own medicine and give it to her. How do I do this?

  2. Dr. Michael Dym, VMD veterinarianAugust 5, 2012 at 6:08 pm

    You will need written script from your vet to treat this condition. You could try antihistamine like chlorphenirimine at dose of 2 mg twice daily, and a oral fatty acid like missing link from 1800petmeds. Some cats though need prescription meds.

  3. Did you figure out what was wrong with your cat? We are having the same issue with our cat. The vet gave did tests, and said it was either an allergy or worm. We treated her with non steroidal meds. It helped, then she relapsed. So they gave her steroidal meds and allergy meds. We weened her off the meds after 2 months, and she was fine. Now, a month later…. She relapsed again! Did you find something to help?

  4. Dr. Michael Dym, VMD veterinarianDecember 10, 2012 at 1:46 pm

    Unfortunately steroids are usually the only effective conventional medical drugs helpful in many of these cases, unless food allergies are found to be contributing. May be worth while to have consult with holistic vet on diet, nutritional supplements and possibly homeopathy as potential long term help. To learn more see or my website Many homeopathic vets offer phone consultations.

  5. Has anyone ever tried colloidal silver and L-lysine to treat Eosinophilic Granuloma in cats? I read about it in an article about natural home remedies for EGC while looking for a treatment without having to use steroids.. I went out and bought a very pure brand of colloidal silver and already had lysine. My cat had a very large ulcer on her upper lip and on her front upper gum. It smelled absolutely awful. I treated her hard with silver her water..which she drinks a lot of water and in her food and flushed her mouth with it. Gave her between 500 to 1000 mg of lysine a day. I checked her mouth tonight and I couldnt believe it. The upper lip was gone..and just a small ulcer was left on her upper gum.. but almost gone too.. And no smell at all. Silver colliodal is amazing stuff..natural antibiotic and tasteless!. The lady who wrote how she cured her cat said that there was a notable difference in a couple days. I gave higher dosages to my cat and i started Saturday and its only Tuesday night…!
    I did not expect that this quick. Wanted to let people know that there is an alternative..since the main treatment is steroids with vets and that only lasts so long..not to mention not being the best for them. If you would’ve saw how bad her mouth was you’d be amazed how great it looks for just being only 3-1\2 days ago!
    I really wanted to share this with people that have a pet suffering from this. I know i will have to keep up until i dont see any sign of it and then make sure it never comes back!

  6. Hello Cindy. Thank you for the wonderful testimonial on the colloidal silver for the rodent ulcers. This is a wonderful natural antimicrobial alternative for holistic minded clients and works wonderfully, but one should only use it intermittently for a few weeks at a time as there can be long term rare reactions when silver is used chronically. For those interested in more holistic approaches to pet health issues, see

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