EGC or Rodent Ulcers in Cats

Eosinophilic Granuloma Complex (EGC) or rodent ulcers in cats are fairly common presentations in clinical practice. Symptoms may include swelling/ulceration of the lips, which can be sometimes accompanied by drooling and can sometimes affect ability to eat. Some cats will have ulcers present on the gums or tongue as well.

Other presentations of EGC include raised hairless plaques or discrete skin swellings in the abdominal/groin area, as well as areas on the legs.

Eosinophilic Granuloma Complex in cats may cause swelling and ulceration of the lips.

Licking or itching of the affected areas is often present in the history.Causes of this syndrome in cats include flea bite allergies, inhalant/contact allergies and/or food allergies.

I will often try many cats with this syndrome on a restricted novel  protein rabbit or venison protein based diet for 2-3 months to see if food allergies are involved.  Topical flea control with Advantage or Frontline Plus is always recommended in cats with these lesions.  Diagnosis of this syndrome is based on clinical appearance during an office visit, and/or aspiration of the plaques, and microscopic exam of the cells on the microscope.

Treatment may include diet changes, flea control, as well as injectable or oral anti-inflammatory therapy with cortisone to decrease swelling and improve comfort until underlying causes are identified.  Since these lesions sometimes become secondarily infected,  antibiotics are often prescribed as well.

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  1. Ive had my cat to vet twice raked up money and her symtoms come back. I want to get my own medicine and give it to her. How do I do this?

  2. Dr. Michael Dym, VMD veterinarianAugust 5, 2012 at 6:08 pm

    You will need written script from your vet to treat this condition. You could try antihistamine like chlorphenirimine at dose of 2 mg twice daily, and a oral fatty acid like missing link from 1800petmeds. Some cats though need prescription meds.

  3. Did you figure out what was wrong with your cat? We are having the same issue with our cat. The vet gave did tests, and said it was either an allergy or worm. We treated her with non steroidal meds. It helped, then she relapsed. So they gave her steroidal meds and allergy meds. We weened her off the meds after 2 months, and she was fine. Now, a month later…. She relapsed again! Did you find something to help?

  4. Dr. Michael Dym, VMD veterinarianDecember 10, 2012 at 1:46 pm

    Unfortunately steroids are usually the only effective conventional medical drugs helpful in many of these cases, unless food allergies are found to be contributing. May be worth while to have consult with holistic vet on diet, nutritional supplements and possibly homeopathy as potential long term help. To learn more see or my website Many homeopathic vets offer phone consultations.

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