PetMeds® Frontline Plus Questions

Some of the more common recent questions I’ve received in the clinic regarding f and its use for flea and tick prevention in pets. A big concern I often receive is the quality of Frontline Plus being carried by online pharmacies like 1800petmeds and whether it is the same as those used and sold by veterinary offices. The truth of the matter is that Frontline Plus is a prepackaged product by Merial, and is the exact same one carried by 1-800-PetMeds as your local veterinarian. Improper application is one of the most common reasons for flea treatment failure

Another common question is, “Why does my pet still have fleas after applying Frontline?” (after a few consecutive months. The most common reasons for flea treatments failing is typically because of improper application, or more commonly failure to treat the environment of the pet, including the home and yard; where 80% of the flea life cycle occurs. Along the same line, some products, however will work better on some pets than others. So, if there are still fleas even after properly treating the home and using Frontline Plus for several months, I would suggest having your house professionally treated by an exterminator and/or change to a different product such as Advantage.

If a pet still has fleas, many veterinarians will use the product more frequently than once monthly, sometimes as often as once every 2-3 weeks. However, this process is often considered to be “off label use,” and I would not use the product this way unless first speaking with your pet’s veterinarian. If a client is currently using a different topical such as Revolution or Advantage, it is safe to change to Frontline Plus after 3-4 weeks from the date of last application of the other product. While Frontline Plus is labeled as waterproof, I usually advise clients to wait at least 24 to 48 hours before bathing their pet. Side effects to Frontline Plus are rare but may include hair loss/skin irritation at site of application, (rarely) digestive upset, (and even rarer) immunological reactions of the blood or neurological reactions like seizures. Again, these are very rare, as most pets tolerate this product quite well.

Related Posts


  1. My dogs are itching from recent flea bites. I have gotten the fleas under control, but theya re still itching. My sister has some Chlorpheniramine 4mg but was dispensed 9/20/07. I am afraid to give this to my dogs but I have heard that meds usually have a 5 year shelf life. Is it safe and if not, what can I do? I have 3 dogs and cannot afford to take them to the vet right now.

  2. You picked a great topic for this post and you wrote about it well. I have seen a couple of other websites with similar content but no one has performed a better job than you on writing about it.

  3. Dr. Michael Dym, VMD veterinarianJuly 8, 2011 at 9:55 pm

    Thank you so much for your kind compliments. We all certainly try hard.

  4. Hi I have one dog two cats and cannot praise Frontline enough – it is easy to apply and works straight away – my pets are flea free and happy.

  5. We used the Frontline Plus on 5 cats. Only 1 cat is still itching and loosing fur on the back of it’s hind legs. The cat was healthy and nice looking B4 this treatment.

  6. Dr. Michael Dym, VMD veterinarianAugust 26, 2011 at 11:27 pm

    Make sure treat home for fleas as well. Also consider antihistamine such as chlorphenirimine at dose of 2 mg twice daily to help with itching.

  7. Is Frontline Combo from Canada the same as or equal to Frontline Plus as they indicate made by same company

  8. Dr. Michael Dym, VMD veterinarianNovember 15, 2011 at 9:53 pm

    Not sure as dont have experience with front line combo from Canada. I would ask drug company

  9. what if i double dose my dog with frontline

  10. Dr. Michael Dym, VMD veterinarianNovember 17, 2011 at 8:13 pm

    Should not be a problem.

  11. I’m getting a dog and already have a (indoor) cat. Is it safe to use frontline on the dog or could I be putting my cat at risk?

  12. Dr. Michael Dym, VMD veterinarianNovember 20, 2011 at 7:26 pm

    There should not be a problem in using front line on dog with cat in house

  13. my vet gave me nitenpyram pills for my dog for fleas, she is already on frontline, how does the nitepyram pills work?

  14. Dr. Michael Dym, VMD veterinarianDecember 3, 2011 at 1:06 pm

    The nitenpyram pills work as an insecticide to kill adult fleas by paralyzing the nervous system of the flea, while not affecting the pet’s nervous system in any way. Marketed as capstar, these oral pills work very quickly to kill adult fleas, but you will need other topical medicines such as front line or advantage or oral program to control the immature stages of the fleas.

  15. Have a 20lb. dog and 80 lb. dog, it I bought a package of Frontline for the smaller dog, could I use 2 or 3 doses for the large dog safely? We only need this for boarding and don’t need it at home, so I’m trying to save money.

  16. Dr. Michael Dym, VMD veterinarianApril 30, 2012 at 6:33 pm

    Using 2 doses would be fine on larger dog.

  17. I have chihuahuas and I use up to 22lbs of Frontline Plus and Interceptor monthly. The day after I gave my older dog this (she is 5) last night she had like a seizure. It was like her legs were pulling up and her neck was extended. She was not shaking, but was really unable to walk or stand on her own for about 5 minutes. Then she was fine as though it never happened. Do these drugs ever cause this kind of side effect?

  18. Dr. Michael Dym, VMD veterinarianMay 14, 2012 at 10:24 pm

    On rare occasions, topical pesticides of any kind can cause neurological reactions in sensitive pets.

  19. I heard from another dog owner who has treated her dog with success for years with Frontline Plus. She said that all of a sudden, Frontline ceased to be effective. Coincidentally about a month later while at my vet’s office, I asked to purchase a package of Frontline Plus that I, also, have used on my dog successfully during the 8 years I have had her. My vet said he doesn’t sell it anymore because he has found that, for some reason, Frontline seems to have lost effectiveness. There it is – the same observation from two totally separate sources.

    Has there been any talk of this in the larger veterinary circles.

    I tried Advantix II, but that caused serious flaking on my dogs skin. I am now trying Advantage II, and I will see what happens. I would like to return to Frontline, however.

    I await your reply

  20. I have used frontline plus for as long as it has been – i have 5 dogs and 3 cats and this year (not missing a treatment) i was so full of fleas both on the animals and in my house – i called the merial company 2 times with no explanation and i am so dissapointed in that i have never ever had fleas before and what a problem ridding myself of them. – i have flea bathed all 8 animals – flea combed – bombed – dusted – and am slowly winning – i started with advantage II for both animals and seems to be working – frontline has really dissapointed me after years of faithful use.

  21. Dr. Michael Dym, VMD veterinarianSeptember 3, 2012 at 9:38 pm

    Thanks for sharing. There have been increasing reports of some resistance to some of the topical flea products developing.

  22. I have always used frontline plus on my animals and up untill the last couple of months it has stopped working I keep finding fleas on my dog. I’m upset because it is expensive to begin with and now I have to pay to get rid of the fleas that I shouldn’t have because I treat my dog and cat every month. My last dog was on frontline plus for years and I never had a problem with fleas or ticks. I wonder if they cut back on the active ingredients in this product?

  23. Dr. Michael Dym, VMD veterinarianSeptember 20, 2012 at 6:27 pm

    No ingredients are the same. Some people have reported flea outbreaks in treated animals. Try alternative product like comfortis from 1800petmeds.

  24. I have been using Certifect on one of my dogs, and the others in the house were using Advantix. I had typically been using Frontline Plus on the dog who was getting Certifect, and have used it numerous times in the past. After 6 months of use of Certifect, the dog had fleas. The other two dogs who were on Advantix did not. They all sleep on the same surfaces, often right next to each other, and two of the dogs, the one on Certifect and one on Advantix sleep in my bed with me every night. So, the Advantix treated dogs were definitely exposed. I’ll be putting the one dog back on Advantix. My mom bought Frontline for the other two dogs, which will be returned.

  25. Dr. Michael Dym, VMD veterinarianOctober 12, 2012 at 6:22 pm

    Thanks or sharing. Sounds like good plan to put dog back on advantix.

  26. I applied Frontline Plus on my dog couple of hours ago and then now, he’s itching. Why’s that? Is it normal?

  27. I have a 26 lb indoor cat that got out for only a few minutes and now has a ton of flea dirt. I gave him a flea bath to with Sentry and also applied the monthly Sentry treatment. This didn’t work. My order from 1-800-PetMeds for Frontline plus should be arriving in a day or so. I will give him another bath before I apply it. My question is, since he is so big, can I double Dose him?

  28. Dr. Michael Dym, VMD veterinarianNovember 15, 2012 at 12:30 pm

    I would not double dose him. Try oral capstar and program as well from 1800petmeds.

  29. I use frontline plus on my dog, she is 42 lbs.I used the pills that are for dogs 25-44 lbs. Should I go to the higher dose or keep it at the smaller one. (she is so close to 44 lbs.}Thanks

  30. Dr. Michael Dym, VMD veterinarianNovember 20, 2012 at 8:40 pm

    Staying at the lower dose should be fine as long as she is not a puppy and growing.

  31. Hi. I’ve been using Frontline for my cats regularly once every 4 weeks for the last 2 years, and just recently tried Frontline Plus. My question is, if I use the same product for a long period of time, do I need to change to a different brand such as Revolution, because I heard mix information about this, 1 vet told me to change every once in a while to avoid the cat being immuned to the medicine, and another Vet told it is fine to use Frontline or 1 brand without changing it once in a while. Which one is correct? Tx.

  32. Dr. Michael Dym, VMD veterinarianJanuary 21, 2013 at 1:31 pm

    As long as front line is working for you I would continue using it. If start to see fleas, change to different product like revolution, etc

  33. hi,
    my experience using frontline, I see fleas usually after 3rd week, is that normal? or maybe like you mentioned in the article about frontline, it’s the way I’ve been applying it, not always correct, mainly because the cat could not stay still.

  34. Dr. Michael Dym, VMD veterinarianJanuary 21, 2013 at 10:56 pm

    Could be inappropriate application or could be heavy flea infestation. Some cases need more frequent every 3 weeks application.

  35. Symba, my 3 yr old tabby gets treatments about every other month in the cold season hence, she is not used to it and squirmed enough that Instead of applying the advantage on her skin, it made it on her fur which is fairly easily reachable to her. Can I just apply another in the correct area? Or I was thinking 3 weeks like the previous question? Thank you in advance Doc.

  36. Dr. Michael Dym, VMD veterinarianMarch 29, 2013 at 7:06 am

    Hi Ryan…..I would wait a few weeks before reapplying. You can use oral comfortis if fleas remain a problem in meantime.

  37. ok I was wondering is there a pill out there I can get for my dog I belive she as a hormone imbalance form her surgery and gained a lot of weight we stil owe 8 hundred on her bill yet couls we purchas a pill from petmeds or some where to help her hormones and a pil to help with her weight we have cut back on everything for her walk and run her no luck thanks

  38. Dr. Michael Dym, VMD veterinarianApril 23, 2013 at 8:50 am

    No magic pill for what you are asking about. Have thyroid checked at vet to see if thyroid levels are low.


  40. Dr. Michael Dym, VMD veterinarianMay 31, 2013 at 10:35 pm

    Try oral comfortis or topical revolution from 1800petmeds as my first choices.

  41. my dogs got a bath and were dried good and I am still seeing a lot of fleas can I reply frontline after 1 week

  42. Dr. Michael Dym, VMD veterinarianJune 2, 2013 at 9:40 pm

    I dont usually apply more than every few weeks. consider alternative flea product like comfortis from 1800petmeds.

  43. thank you for your response. is it okay to give this same kitten fronline plus? it has been 3 weeks since the first topical flea treatment was applied. she is now 11 weeks old

  44. Dr. Michael Dym, VMD veterinarianJune 4, 2013 at 4:08 pm

    Should be fine to apply.

  45. can I put frontline on my dog that is pregnant?

  46. Dr. Michael Dym, VMD veterinarianJuly 7, 2013 at 10:24 pm

    I dont like using front line on pregnant pets.

  47. Hello, out of desperation I gave my dog hartz ultra guard pro when I found she was fighting some fleas. This was late at night after vet closed and all I had on hand. About six days later, I gave her a bath and applied frontline plus. Was this okay? Will I see complications from this double dose and if so, what signs/symptoms should I be on the lookout for?

  48. Dr. Michael Dym, VMD veterinarianOctober 21, 2013 at 11:34 pm

    I dont think this extra front line dose will be a problem.

  49. It’s time for my four cats to use frontline for the fourth month in a row. They still have live fleas all over them. Is it safe to use a flea shampoo on them just before the next treatment?

  50. Dr. Michael Dym, VMD veterinarianOctober 24, 2013 at 7:03 pm

    i think not a problem as long as 48 hours apart from next treatment

  51. I have to treat 2 cats with Frontline for the first time. What if one of them gets in contact with the Frontline that I applied on the other cat.

  52. Dr. Michael Dym, VMD veterinarianJanuary 9, 2014 at 1:42 am

    Try to prevent this by keeping them apart for a few hours. If in doubt of exposure have vet assessment

  53. I used Frontline Plus for several yrs on my 3 cats. After noticing that frontline’s effective had decreased I have been using Advantage ll for about a yr. I still have a supply of frontline and would like your opinion if frontline’s effectiveness may return after a yr of non-use on my cats. Also would it be ok to use frontline one month and advantage the next month. Maybe like that the fleas would not become immune to either. Any thoughts?

  54. Dr. Michael Dym, VMD veterinarianJanuary 23, 2014 at 3:44 pm

    No problem alternating flea products monthly. I dont think this issue has ever been studied.

  55. I have 3 cats all inside/ outdoors. As soon as they got fleas this summer I bathed them and waited 2 days till I applied front line plus for cats. My long haired kitty still has them crawling all over, its been 8 days…the other 2 seem better but I’ve seen some on them 2 just not as many. I have not seen a flea in my house and I wash everything once a week. Should I wait the remainder of the 30 days and apply another dose or try something else? I don’t want him to suffer the fleas or possibly get tapeworm.

  56. Dr. Michael Dym, VMD veterinarianJune 13, 2014 at 6:45 pm

    I have found front line not as effective as it used to be in some cases, as well as people often forget to treat the environment or home of pets, where most of flea life cycle occurs. I would try a different product like comfortis from 1800petmeds.

  57. I used wilkos own flea treatment on my cat 3 weeks ago and it’s not done a thing. Can I use frontline so soon or wait another week? Thanks in advance

  58. Never mind due tomorrow. Thought I.would get a quick reply

  59. Ernestine JosephJuly 1, 2014 at 2:59 am

    i used a Hartz ultra Guard on my 37 then i realized it stated on the tube ‘for dogs over 60 lbs’ should i bathe him right away to take the il off? . is my dog going to break out out? is he going to be okay?

  60. Ernestine JosephJuly 1, 2014 at 3:02 am

    i used a ultra gaurd on my 37lb. dog then i read the tube (which i should have done 1st) and noticed it stated for ‘dogs over 60 lbs.) will my dog be okay? will it make him sick? should i bathe him and take it off?

  61. Ernestine JosephJuly 1, 2014 at 3:04 am

    i used an “ULTRA GUARD on my 37lb dog…then i noticed the tube says ‘FOR DOGS OVER 60 LBS. will my dog be okay?

  62. Ernestine JosephJuly 1, 2014 at 3:05 am

    i used an “ULTRA GUARD on my 37lb dog…then i noticed the tube says ‘FOR DOGS OVER 60 LBS. will my dog be ok

  63. Can I apply frontline right after my dog’s bath or do I have to wait

  64. Dr. Michael Dym, VMD veterinarianAugust 6, 2014 at 2:20 pm

    Although it is supposed to be water proof, I usually wait 48 hours after application to bathe your pet

  65. I have always used Frontline on my two cats with no problem but this summer it has not worked at all for the last three applications.It seems to have no effect whatsoever on the fleas. I have treated the house. Can I use another treatment before waiting four weeks and which would you recommend?

  66. Dr. Michael Dym, VMD veterinarianAugust 9, 2014 at 2:26 pm

    I would try another product like oral comfortis from 1800petmeds.

  67. I applied hartz spot treatment to my dogs 8 days ago. Didn’t work and of course I would have used if I had known. I’ve bathed them 3 times with Dawn within 3 days following. I have them a capstar that worked for the 24 hours but they are itching again. We are getting in a car for a 15 hour drive to move. Can I give them advantix and a cap star before we get in the car 10 days after the hartz so we make sure we do t take any fleas with us?
    I do t want to make them sick or hurt them with to many chemicals. We are bombing the house which will be empty for awhile but we do t want to take any fleas with us they are small dogs

  68. Dr. Michael Dym, VMD veterinarianAugust 10, 2014 at 2:54 pm

    I dont think you have a choice but to use another flea medicine like advantix, as well as capstar as needed to treat adult fleas.

  69. I have used Frontline and Advantage off and on for my golden retriever with average success. In the area we live my vet says that over the past years the fleas have built up resistance to both drugs. 2 years ago my dog developed cancer, Mast Cell Tumor, Grade II Stage. We only found one tumor and had it successfully resected with wide margins and to date no other tumors. At the time of diagnosis I stopped all topical flea treatments and only occasionally used Capstar through the warmer months in Coronado, CA (San Diego). This summer however in uncommon humidity we are having a horrible time with fleas and I have done Everything non systemic. I have two vets and one oncologist and they all want to give comfortis or some other oral pesticide. I am frankly concerned about giving oral pesticides of this magnitude to a cancer dog with an already compromised immune system and have read hundreds of bad reviews about comfortis as well as the new Seresta (sp?) collar. Any other treatments or thoughts come to mind? Thank you!

  70. Dr. Michael Dym, VMD veterinarianAugust 17, 2014 at 2:16 pm

    With a history of mast cell cancer, I would try natural flea treatments like the one from vetri science, which you can google on line, as well as or It also may help to consult with a holistic veterinarian. If you have to use chemical preventatives, I would consider topical revolution, which I find safest of the bunch in my opinion.

  71. thank you so very much, I appreciate your opinion. Someone mentioned Skin So Soft Oil diluted half half with water, an Avon Bath oil with side effects of a bug repellent is also affective on dogs. I have been using this with success over the past few days if I spray him before and after our walks. If I go to another topical I will try Revolution which I have never tried before. I have tried Wondercide flea repellent and my golden seemed to have a reaction to it – very lethargic, seemingly depressed and a bit sick overall. A holistic vet is also an option, but I would be surprised if they could suggest anything holistic I haven’t researched and tried over the past few years, and I am not in a hurry to a fourth vet to our mix, it’s hard enough juggling 3 with different opinions! 🙂 Thank you again for your response, I will look for the vetri science treatment online.

  72. One last question, the Vetri Science topical you mention above contains 9.7 % Fipronil which is the same ingredient as Frontline – 9.8% Fipronil. Is there something I am missing about “the natural” recommendation you mentioned or is there a different flea treatment you were referring to from Vetri Science? Thanks again.

  73. Dr. Michael Dym, VMD veterinarianAugust 18, 2014 at 9:31 pm

    Hi Caroline. I am not familiar with fact that vetri science is using a fiprinil based product. As far as I knew it was an essential oil and/or cedar product. I would contact the vetri science company directly for clarification on this issue.

  74. Dr. Michael Dym, VMD veterinarianAugust 18, 2014 at 9:32 pm

    Hi Caroline. Also consider some of the great natural products for flea/tick control from my friend Bill, owner of

  75. Help! My almost 18 year old healthy golden cocker lab terrier mix is infested with fleas. She’s been on frontline advantage advantix all her life and it’s never been this bad! It’s 25 days into the month and I’m wondering if I can give her August 29th application today? I’ve washed her and her linens and sprayed them along with the house using natural products. I brush her several times an hour and the more I brush the more fleas I find. Your advice would be greatly appreciated. Thank you do much!

  76. Almee – you can give Frontline/Advantage every 3 weeks (I am not a vet but my own vet has told me this). Capstar (one pill good for 24 hours) will kill every flea on her while you are waiting for the spot treatment to settle into the skin. Capstar is from your vet or petmeds also. Hope this helps.

  77. Hi Caroline. Thank you. I just have her another real good combing, sprayed her beds house again and applied frontline.
    She scarfed down a nice dinner and several cookies and is napping comfortably. Thank you!

  78. Sure Almee. Before my dog got cancer I used spot treatments every three weeks in conjunction with Capstar if I saw a flea on her in between times and after every bath (you must wait 24 hours after bath (to completely dry) before applying spot treatments. The capstar kept him free of fleas for the day before I could reapply the Frontline. Next time you get your Frontline make sure you get some Capstar for times like this. Make sure you vacuum every day now for the next week as well as washing bedding daily until you break that cycle and the larvae and eggs are all gone as well. Good luck!

  79. You’re a good person Caroline. Thank you for all the tips and for caring! Best to you….

  80. Dr. Michael Dym, VMD veterinarianAugust 28, 2014 at 6:21 pm

    Fine to use the advantix a bit earlier, but I would consider alternative flea/tick product such as trifexis, comfortis, or topical revolution. Also remember you may need to treat home as well with good product like flea busters which you can find on line. Much of flea life cycle occurs in home

  81. can frontline plus for cats 8 weeks and older be used on a dog that weighs approx. 15 lbs. and is 13 months old?

  82. Dr. Michael Dym, VMD veterinarianAugust 31, 2014 at 7:58 pm

    I dont use topical front line products off label. I use the products as packaged and labelled

  83. Hi,
    We have an indoor car with fleas, we gave him frontline about a week ago and a bath with flea shampoo last night. He still had fleas, when is the soonest I can give him another dose of frontline?

  84. Dr. Michael Dym, VMD veterinarianSeptember 26, 2014 at 9:37 pm

    Usually I would wait at least 2 weeks between front line doses. However if situation severe, consider also dosing with oral comfortis, which I think will work better for you

  85. Hi,we found fleas on my 5 yr old 10lb dog a week ago, We bathed him and applied frontline plus. I vacuumed washed and sprayed everything for the past week. We gave him a capgaurd pill (same as capstar) 3 days after appling frontline and then I gave him a flea shampoo bath 3 days after that (still seen live fleas on him). I have vacuumed the entire house everyday and emptied canister from vac outside. Only see fleas on the dog. I treated the yard the day after I found fleas on him. Today is 1 wk 2 days and I found 2 live fleas on the dog. Help:( called frontline and they assured me that the product is working and I can use another spot on treatment with the frontline. They said double dose don’t hurt the pet it’s just a waste of product. It’s been 9 days should I still see fleas???

  86. Dr. Michael Dym, VMD veterinarianOctober 13, 2014 at 3:39 pm

    You likely have problem in the dog’s environment so important to have house and/or yard treated professionally. Also consider oral comfortis from 1800petmeds, which I have had much greater success with in recent years over front line

  87. Hi, I used Sentry flea medication on my cat last Sunday because the pet store was out of frontline plus. I went back yesterday and bought some frontline plus. Is it okay to apply it to her today after its only been a week with the sentry?

  88. Erica, I am not a vet but I think it is too soon to apply the Frontline. Call your vet and ask as I am not familiar with Sentry. However, cats are highly sensitive to topical flea medications and frequently can have reactions. If it were my cat I wouldn’t risk it so call your vet and ask as soon as possible 🙂

  89. Dr. Michael Dym, VMD veterinarianOctober 26, 2014 at 8:22 pm

    I would wait one more week before applying

  90. Hello. Thank you for your help. Our two indoor/outdoor cats have a flea issue. We have fogged our home quite thoroughly, washed the cats bedding, our bedding,vacuumed the house completely. Sprayed our furniture. We have never seen any in the home, only on the cats. We have treated them with Frontline plus every 3 weeks for the past 3 cycles and they still have fleas. We can only expose ourselves to chemicals so many times.. (Meaning, i dont want to to keep fogging…)… Any suggestions? . Thank you

  91. Dr. Michael Dym, VMD veterinarianNovember 19, 2014 at 5:14 pm

    Try oral comfortis from 1800petmeds which has been approved for cats for flea control and prevention.

  92. I have a 20 lb dog. Is it ok to give the 23 to 44 lb. dose. The store was out of the smaller dosage.

  93. Is it ok to give frontline 23-44 lb dose to a 20 lb dog?

  94. Hi I use Advantage on my golden retriever only when I need to but it seems in Coronado, CA the fleas have become resistant to most everything. My boy has cancer so I will not use a systemic tabs such as Comfortis and have also tried natural repellant sprays from Mercola. Our house is clean but he must be picking up a few fleas on walks as when I brush him every day I occasionally see one or two. I know they die when they bite him from the Advantage, as I see a dead one on his white covered dog bed now and then but the flea bites make him crazy. His skin looks wonderful, no visible bites or red marks, he gets bathed every two weeks with an enzymatic shampoo. Everything is spotless and clean but I believe he may now have a psychological itching. He doesn’t scratch in front of me but when I return home from being gone he has pulled out hair everywhere. When we talk walks and he meets another person or dog he immediately sits down and scratches outrageously. He has been on prednisone oral for awhile which helped but I hate giving it to him with his cancer. I have heard about Apoquel but have never tried it. Any suggestions? Is there such a think as psychological itching? Or could occasional flea bites make him itch constantly. He is almost 10 years old and I also wondered if this might be a senior oddity. Thanks so much sorry for the long post.

  95. Dr. Michael Dym, VMD veterinarianJanuary 25, 2015 at 3:42 pm

    Flea bites and/or other type allergies, including environmental inhalent/contact allergies known as atopy may be involved. I DOUBT problem is psychological. Low dose pred may be best choice to control itching or mild combination product like temaril p which has VERY low dose pred in it, as well as antihistamine. Unfortunately apoquel is NOT to be used in patient with cancer

  96. Dr. Michael Dym, VMD veterinarianJanuary 25, 2015 at 3:47 pm

    I dont think it should be a problem, as long as no history of allergic reactions.

  97. Thanks so much Dr. Dym, I did not know about the contraindications with Apoquel and cancer as I had not researched the drug yet. Yes it was Temaril P he was on before that worked well for his itching, although the first few weeks of loading doses made him really tired and depressed seeming. I guess that looks like my next step though, I have ruled pretty much else out, maybe I can wean him down eventually to one tab of Temaril P every other day after all the loading doses and a month or so on one tab daily. I appreciate your input very much.

  98. I used Sentry PurrScriptions for cats 5 lbs. and over on my adult cat that weights about 20 lbs a week ago and saw no results. Is it okay to use Advantage II for large cats within about a week of using the Sentry?

  99. I just bathed my dog and noticed he just got fleas. Can I use frontline plus right away? Or do I have to wait? I saw a vet on YouTube say if you bathed your dog wait 48 hours before applying frontline plus. Please help me: ( I know after I apply frontline plus to wait 48 hours before bathing. But if I just bathed him and he’s dry can I apply now or wait 48 hours. Please respond fast. Thank u

  100. I just bathed my dog and noticed he just got fleas. Can I use frontline plus right away? Or do I have to wait? I saw a vet on YouTube say if you bathed your dog wait 48 hours before applying frontline plus. Please help me: (

  101. Dr. Michael Dym, VMD veterinarianMarch 18, 2015 at 1:03 pm

    Usually must wait 48 hours to apply front line after a bath. Other option I prefer here is the oral pill comfortis which I think is much more effective.

  102. Dr. Michael Dym, VMD veterinarianMarch 18, 2015 at 1:33 pm

    Should be able to use advantage here without a problem, even if sentry just applied.

  103. My puppy is 37 pounds (and growing) and I just realized I have the frontline plus for 45-88 pounds. Is it ok to give to her or should I just give her half of the large dosage? (Looks like the ounces in the 23-44 pound are exactly half)

  104. My puppy is 37 pounds and I have the frontline plus for 45-88 pounds. Is it ok to give to her or should I just give her half of the large dosage? (Looks like the ounces in the 23-44 pound are exactly half)

  105. Dr. Michael Dym, VMD veterinarianMarch 24, 2015 at 12:15 am

    I would give him the higher dose. Should not be a problem.

  106. My black cat has fleas – she’s an indoor cat and only ventures out for a few minutes every so often to chew on grass. We aren’t sure how she got fleas, but she got them, possibly from sitting in the windows because our neighbor’s yard is like a jungle and we live in row houses, so the yards are connected. We bathed her with apple cider vinegar and cat shampoo, combed her, dried her, and applied Ultraguard Pro. Not sure it did the trick, and since the house is full of fleas and we are trying to manage it, we’ve quarantined her to the bathroom. I’d like to be sure that she is safe to come out and roam so that the fleas go after her and die. Is it safe to apply Advantage II after one week? I have two small children who have tons of bites right now – we are having a hard time controlling this. Thanks, in advance!

  107. Do you love your pet? Then don’t use Frontline, Advantage, or Advantix!
    Topical flea, tick, and de-worming products such as Frontline and Advntix are toxic and can cause pets to have mild to extremely adverse effects. Many products have different active ingredients, but they all work in similiar and harmful ways. They are toxic.
    Unfortunateely, we were one of the life-threatening cases after applying this stuff.
    Our German Shepherd had an adverse reaction FOUR times to different brands of what is basically the same thing. The first time she became so lethargic she didn’t eat or drink much for a few months. She slept ALL the time and didn’t even bark when the doorbell rang (she ALWAYS barks!) Took her to the vet 3 different times and said they couldn’t find anything wrong other than dehydration. I asked about a correlation with this product and they said NO WAY!
    Applied the product a 2nd time 6 months later, and noticed the same odd behavior and unsteadiness. The vet again said it couldn’t be the topical we gave her and thought she was depressed from being lonely.
    Gave her the 3rd dose about 6 months later because she was scratching so much. I thought she had fleas and the vet insisted it was safe. Within three hours, my dog had no control over her hind legs and was panicking and shaking uncontrollably. I will never forget the fear in her eyes. Took her to the emergency room. By the time we arrived, she i could walk but was not herself. The vet did thorough blood work and found nothing. I showed him the box of Frontline I applied and said over and over again I thought it was the cause of these problems, but he insisted it wasn’t possible. He said the side effects included on the box was preventative and it would take such an extremely high dose to have any kind of reaction it wasn’t really possible.
    A month later, we found our dog on the floor convulsing, foaming at the mouth, and completely paralyzed. She couldn’t breathe and we thought we were watching her die. It was horrifying to witness. We calmed her down enough to stop the convulsing and took her to the emergency room again. They admitted her into ICU for a week! Tested and x-rayed her for possible meningitis or spinal tumor, but still found nothing wrong.
    Took her to a new vet who also insisted it couldn’t be the topical, but my gut still knew otherwise. She gave us a different brand to use because it had different active ingredients and insisted it would be fine. I never used it, though, for fear of another adverse reaction.
    A year later, which is now, our dog had her fourth topical treatment. We found several ticks, worms in her stool, and she was scratching a lot. I got out the Advantage Multi our vet sold us and insisted was safe, even for our dog who had severe reactions with Frontline in the past, and applied it. Six hours later, we found her on the carpet seizuring. She was unable to move and had no control over her bowls. I knew it was the Advantage Multi I put on her. This could not be a coincidence FOUR times!
    Called the Advantage Emergency Hotline and she said they’d never heard of a reaction before and she couldn’t tell me how to get this stuff off or what to do. She was only interested in the lot number on the Advantage box! I told her she should Google what this product is doing to people’s pets. There are thousands of pet owners online complaining of these same adverse reactions to these flea and tick products.
    We got our dog in the tub right away and shampooed as much of this out as we could (I know now to use Blue Dawn Liquid Dish Soap instead of shampoo because it’s a better de-greaser to get this waterproof product off. These products start absorbing into the skin immediately, so time is of the essence. Once the Advantage Multi was removed, our dog became noticeably better.
    Time will only tell if she will have residual complications from this as she has in the past.
    No one should be applying these toxic flea, tick, and worm prevention products to their pets. They can cause neurological damage, renal failure, skin disease, and even death. They are pesticides that are not safe for animal or human contact and need to be investigated.

  108. I have a 35 pound begal but accidentally bought – pound frontline. Is it ok to still use it on her?

  109. I have a 35 pound begal but accidentally bought 45 – 88 pound frontline. Is it ok to still use it on her?

  110. I would not use the front line labelled for a dog on a cat.

  111. Isn’t small doses of frontline plus for 5-22lb dogs a bit of a weight difference? I always fret when it is time to dose, though I buy product for big dogs and use syringe. We have 7 dogs of all weights. I had a dog that had a seizure from this. A mild one, but scared me. This year in Missouri the fleas came out and we had a hard time getting under contro, we just never had problems before this yearl. Finally Advantage spray, after trying a couple natural ones, gave dogs relief. Treating carpets and such also is a must. Our only worry in past years were ticks, but this year fleas were maddening. Time to apply FL plus again and fretting about using Advantage and FL together. Really would love advice on this please. If I have to choose one it would be the Spray cause fleas abandon ship when they get this sprayed on the dogs. Have to do once a week or so but dogs were suffering so badly.

  112. I was reading some of comments about dangers. I have always worried about this, but nothing “natural’ worked after spending a small fortune.The clove spray worked while wet on dogs but next day, wham, that gets expensive spaying it everyday. Treating surroundings is a must but only goes so far. When pets are suffering and getting sores from digging you just can’t experiment with this and that till you solve the problem. I had to break down and take a chance. Now sores and fleas are under control. I have experienced the dangers of chemicals on pets as a siezure a few years back, Once and only once and now choose not to let them be miserable, but you need to be smart about it and research the best products available first. If fleas got maddening for me just watching dogs dig into themselves, imagine what they are going through. I am conservative with dosage and then ask questions if I have them.

  113. I would use EITHER advantage or Front line. I dont use both. If either of these not working for you, you can consider trying oral comfortis and/or nexguard, which is also effective. I do recommend treating home and usually have it professionally exterminated if problem very bad

  114. Excellent points Nancy

  115. This is kind of an unusual situation in that i have a medical condition (chronic pancreatitis–11years now, which leaves me unable to do much at all). I saw my male cat, Pilar (14 years old) scratching himself horrifically, and literally tearing out his fur. Now he has fur, but only in on the top of his head com on the top of his upper body. The hair beneath his ears is virtually gone, and where there is “no hair” on the rest of his body, it’s just wisps of thin, white hair. His stomach has no more hair and is pink skin.
    I saw NO fleas–anywhere, and started wondering if this was a senility issue. Finally I saw a giant flea crawling across where he still has a good coat of (white) hair: on his neck.
    I immediately, which is something I rarely do, do to the pain i experience, went to PetSmart and bought Frontline, came back home and applied it. I didn’t do it right, so against my own knowledge, and in complete fear i re-applied it, correctly, the next day, and he was listless. It seemed to work. (P.S. Pilar is a surely INDOOR cat, and I never leave the house–except for emergencies, so I’m still perplexed as to how this all started). He slept all day, but he’s not drinking his water, and the fleas that seemed to die/disappear after that second dose seemed taken care of. I understand that environment maintenance is crucial, but I don’t have a working vacuum, and even if I did, it’s such a large place it would take me many times of rest to complete the vacuuming process. Instead I ordered Raid flea control and sprayed it (as described on the bottle) in His two usual lounging-spots, and also just everywhere. For about 3 days it looked like all was well.

    Now, for the first time, I’ve found 3 fleas (lively, easily escaped) on ME, and other than lying around, Lar is simply in a state of terror: constantly shaking his head frantically, responding rapidly to a bite, ripping out hair again…etc. the look in his eyes is one of confused terror, and for the last 7 years that I stopped being able to function, he’s been my only pal. Needless to say, I have had him since he was a baby, and this is all I can think about. He deserves better. I’m scared and utterly sad, and he’s terrified.
    What should I do? I’m afraid to go to c vet because they’ll just saw the obvious. I’m unable myself to do the things required: foggers, vacuuming etc, and even if I COULD, I REFUSE to issue him a THIRD dose of Frontline in just 3weeks. I don’t want Lar to die. He’s so old. Is there a company that does these things for people who are medically incapable? I’m right in refusing to give him yet another dose of Frontline in only 3 weeks, right? Any suggestions? I’d like to say thank you, so much, in advance for any answer(s) or info you might have for me. P.S. I live in Portland, OR.

  116. Sounds like you need to look at another flea product such as oral comfortis from 1800petmeds, which will require a script from a local veterinarian. Also sounds like your kitty needs a thorough physical exam and medical evaluation, as well as to see if any prescription meds might help with patient comfort. Given your health situation, I would suggest trying to find a local house call veterinarian in your area

  117. When dosing my golden retriever who is very hyper, he moved and I missed and some of the frontline got on his fur. I am not sure what got down to the skin. Can I give him a second dose? He is about 80 pounds.

  118. HI Gina. I would not dose again, as we arent sure he did not get enough actually applied. I would wait at least 2 weeks, before which you can reapply the product if needed at that time

  119. Hi my I have a 70 lb pitbull! I bought flea medicine for 88lbs or higher, can I use it or should I try and take it back?

  120. I have two indoor cats that recently got fleas. Eleven days ago I bathed both of them with a flea shampoo. I was able to get it all off of one of my cats but the other, who has front claws, tore me up so bad I just had to try to remove the remaining shampoo with a wet towel which still didn’t get it all off. The following day when she was dry but crunchy she vomited several times. I continued to wipe her down but could still see the fleas. So two days ago my neighbor gave me a dose of Revolution per cat and I used it on them. I have vacummed several times, made a mixture of baking soda and salt let it sit on the carpet and vacumned that up. Its been three days since I used the Revolution topical on the cats and the fleas seem to be dying off slowly. I am using a flea comb to get rid of them faster but they are both still itchy. Tonight I poured Borax underneath my couches and scrubbed it in to control the environment without having to use a fogger and I will vacuum it up in the morning. Meanwhile, the cats are still itchy and losing hair everyday. Have I used too much on them or should I use the Frontline that I purchased. I just feel like its too soon to put another topical on them. I don’t have much money but can’t take it anymore! HELP!!!!!

  121. Can I do a second dose of Frontline plus 4 days before the dose date which is 10/30/16? I dosed my dog on 9/30/16 and 3 weeks later he had fleas. Why would he get fleas again once he was treated?

  122. I have used these type of topical products off label sooner than the month has run out. I dont see a problem with using it a bit early. also make sure you treat all animals in the home, as well as remember to treat home with products like Knock out or others, as much of flea life cycle occurs in home environment. Also consider other and better prescription flea products such as comfortis or nexguard, which your vet may have to prescribe for you

  123. i use frontline plus combo for my 2 pomeranians, 6 pounds and 8 pounds.
    I am very diligent using them, exactly one month
    Usually, I buy 12 months supply for their heartgard and frontline plus combo
    Last night, opening the last of my frontline combo for my 2nd pomeranian, i found the pipette was empty and the container was greasy. With magnifying lens, I find a small hole in the pipette as well as the packaging.
    Called, was told they cannot give me replacement, will give me $6.00 credit.
    Tried ordering more but will not arrive in 7-14 days, perhaps 7 days according to different retailer.
    I called Well Clinic, being Saturday, they are closed till Monday.
    Will missing it for that many days create a problem for me?
    Hate to go and bu y anoth er package which is quite expensive as I already ordered another 12 months supply

  124. HI Cristina. I would not worry about not giving the product on time. That should not be a problem. Be patient with it and simply apply when it comes by mail.

  125. My dog is 5 months and only weighs 4 pounds and the frontline plus 5-22 I decided to give my dog a half dose think it would be fine. I’ve seen one flee on him and since giving frontline I still see the one. Is there something I can give him that is safe? It has only been 8 days since I have him frontline.

  126. Would I be able to give him the rest of the dose today?

  127. HI Rachael. I usually dont suggest redosing the front line, even at lower dose, for at least 2 weeks after the initial dose. In future, it may be best to consider an oral prescription medication for fleas if you need additional coverage; i.e such as oral comfortis, etc from 1800petmeds.

Leave a Comment