Pet meds to Help Control Urine Leaking in Senior Dogs

Filed under Dr. Dym's Vet Blog
Using pet meds like Proin can help control leaking urine in some dogs One of the more common urinary complaints of older dogs is when animal guardians start discovering puddles of urine where dogs rest or sleep at night. This common problem is often due to a weakness of the nerves around the urethra, which is the outflow tract of the bladder. When the muscles around the urethra are loose or lax, urine leakage can occur when a dog is resting or asleep.

While this problem is fairly common in spayed and neutered pets there are several effective prescription medicines that can help.  For years we used to use low doses of the estrogen hormone with a product known as Stilbestrol or DES.  However, because of the small risk of hormonal side effects, another drug called phenylpropanolamine or Proin replaced DES as the most common drug of choice in treating incontinent pets.   Most dogs’ urine leaking  can be adequately controlled with Proin in my experience, which acts to tighten the muscles around the urethra.

However, it is important to have a full medical evaluation, including urine analysis and possibly blood work to rule out other potential underlying causes and urinary infections first before prescribing medicines for urine leaking. Other holistic products such as HomeoPet Leaks No More can also be tried, but in my experience these other drugs are much less effective in controlling urinary incontinence or leaking in dogs.


  1. Susan Applegater
    Posted November 7, 2012 at 10:41 am | Permalink

    I seem to remember that years ago we weaned our bitch off the previous medication used for urine leakage and that she didn’t leak for many months. Can one do the same with Proin?

  2. Dr. Michael Dym, VMD veterinarian
    Posted November 7, 2012 at 9:56 pm | Permalink

    You can try weaning dose of proin down but dogs often will relapse over time.

  3. Marcelle Walsh
    Posted October 24, 2013 at 10:20 am | Permalink

    My doctor put my 14 year old female, spayed Yorkie on Proin to stop night leakage. It works, but now she is piddling around the house quite often, something she NEVER did. I am at my wits end. What do I do? Thanks!

  4. Dr. Michael Dym, VMD veterinarian
    Posted October 24, 2013 at 7:06 pm | Permalink

    Ask vet about adjusting dose up of proin and/or consider adding low dose estrogen known as stilbesterol which can help many spayed females.

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