Denamarin: Liver Support for Pets

From one of the most trustworthy nutritional supplement companies on the market, Denamarin is an excellent multifaceted supplements that can significantly improve liver function by increasing liver glutathione levels. The duel main ingredients of SAMe and Silybin (active ingredient of milk thistle) are potent antioxidants that protect liver cells and may even promote liver cell regeneration in dogs with active liver disease.

The product also can help with digestion and absorption of nutrients from the diet as well. There are no negative side effects seen with this product, and on the positive side, pets usually become more active and playful as liver function improves when taking this product.

Increased activity levels are often a noticeable benefit when pets are given Denamarin

It is certainly safe to use long term and even as a preventative in those pets who are also taking medications that may be toxic to the liver such as prescription nonsteroidal anti-inflammatory medications such as Rimadyl, Deramaxx, Previcox or Metacam. The only client concerns I have seen with this product revolve around the cost. However, because of the combination of wonderful synergistic liver supportive ingredients in this one product, it is certainly highly worth it in my opinion and experience.

Related Posts


  1. Is there a generic product available for Denamarin due to the high cost?

  2. Dr. Michael Dym, VMD veterinarianAugust 14, 2011 at 10:43 pm

    You can try SAMe from health food store along with milk thistle as well which would be equivalent to buying the denamarin, however SAMe can get expensive as well.

  3. is denamarin still effective with food…it was recommended to take on an empty stomach but i have a very hard time getting it in my dog

  4. Dr. Michael Dym, VMD veterinarianDecember 21, 2011 at 4:54 pm

    Giving it with food should not be a problem.

  5. What about the generic version of the pill? S-Adenosyl 100MG. I assume there are no problems with the generic? It does not seem to be available on petmeds yet, but I have found it on other websites.

  6. Dr. Michael Dym, VMD veterinarianDecember 28, 2011 at 2:28 pm

    The generic version should be fine for liver support.

  7. How many mg. of Milk Thistle?

  8. Dr. Michael Dym, VMD veterinarianApril 22, 2012 at 9:10 pm

    50-100 mg is typical dose daily.

  9. I was also told by my vet to only give Denamarin without food. I tried for 15 minutes and got one pill down and in trying the second one my dog would not let me and I almost got bitten because he would not let me open his mouth. I do understand that it works better on an empty stomache, but a pill with a tiny bit of food should be better than none at all?

  10. Dr. Michael Dym, VMD veterinarianJune 2, 2014 at 6:06 pm

    I dont find giving this supplement with a bit of food a problem

  11. I am curious about using this on a dog with Hepatocellular Carcinoma. My dog had a very large (5.5 lbs) grade 2 HCC removed 2 years ago. She has been doing very well in these last two years. However, we did a CBC and abdominal ultrasound recently, in preparation to remove a Grade 3 Mast Cell Tumor from her ear, and discovered she had slightly elevated liver enzymes. Aspirates from a small mass on her liver–in the area where remnants from her liver lobectomy was done–indicate a probable return of the HCC. If Denamarin is protective against liver cell death, am I giving the cancer cells a boost at the same time I am helping her healthier liver cells? Has any research been done? I am not too worried about the HCC on its own, as it is small at this time, slow growing, and my dog is already 13 years old (though you would never know it to look at and hang out with her!). I like the positive impact of Denamarin, but I don’t want to encourage the HCC to thrive either. Any insights would be appreciated.

  12. Dr. Michael Dym, VMD veterinarianOctober 9, 2014 at 3:58 am

    I dont think the main ingredients in the denamarin would affect the tumor in a negative way as the two main ingredients milk thistle and SAMe are both antioxidants and liver cell protectants for the general organ. There are no contraindications with this product as far as I know from a promoting cancer perspective. You also may want to consult with a holistic veterinarian as well on other supportive holistic care that may help her at this age, rather than putting her through more surgery and/or chemo/radiation, etc

  13. Thank you so much for the reply. I WOULD like to follow up with a holistic practitioner, as I am currently really struggling with the decision making process as far as the MCT goes. We have recommendations for a second, more aggressive surgery on her ear, with a probable full ablation being the result, followed by ‘lifetime’ treatment with Palladia. It sounds like a lot. She is a vibrant and active 13 year old–for all appearances, half her age–butt still, she is 13, and I don’t want to overwhelm her. She has bounced back from her previous surgeries beautifully…the removal of the HCC at the age of 11, and the partial ear removal from the MCT just about a month ago. But I hate to keep putting her through it. I will see if I can find a good holistic practitioner to consult with. We already use a lot of nutritional and supplemental support–K9 Immunity, home cooking, and just started with the Denamarin. I just wish the MCT wasn’t such a scary and unpredictable cancer.

  14. Dr. Michael Dym, VMD veterinarianOctober 10, 2014 at 5:10 pm

    Palladia is an excellent drug but certainly very expensive costing hundreds of dollars a month. A holistic consultation certainly would be a good option

  15. Helpful article . I Appreciate the insight – Does anyone know if my business can access a sample a form example to type on ?

  16. Hello Thomasina Baier. my partner found a sample TN DoR SLS 450 document using this you can access a sample a form example to type on that link

  17. Our vet gave our cat 10 tablets of 90mg Denamarin because her liver readings were a little elevated. He said not dangerous levels. She seems much more active. Was wondering if I could give her 5 Denamarin tablets every quarter as maintenance. Will ask vet to do blood work when she gets her yearly exam and vaccines. Are there any side effects that may happen from the quarterly dose of 5 Denamarin tablets?

  18. Hi Brenda and thank you for your question. For any medical concerns, we always recommend you consult your veterinarian, or you can discuss pet medications with one of our pharmacists at 1-888-738-6331. For non-emergency questions, you can contact Dr. Dym directly using our Ask the Vet form.
    ~ Abby, PetMeds Pro

  19. My vet Took the dog off Denamarin and now he is sluggish and vomiting. vet said it is not recommended for
    long term use?? He has Liver Shunt that reoccured 2 years after surgery. I wonder if he should go back
    on the Denamarin since he was doing well on it ?

  20. Hi William and thank you for your question. For any medical concerns, we always recommend you consult your veterinarian. However, for non-emergency questions, you can contact Dr. Dym directly using our Ask the Vet form. We hope your dog is feeling better soon!
    ~ Abby, PetMeds Pro

  21. We are just putting our dog on Denamarin 425 Mg, we were not provided any instruction about with or without food. Today I gave her the pill and then fed her about 5 minutes later. Is tah ok or should I change my approach?

  22. How long does it take to see results from this product

  23. Hi Laurie. According to the manufacturer, “Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denamarin and how it may be helping to improve your pet’s liver function. At home, watch for improvements in attitude, appetite, and activity level.”
    ~ Abby, PetMeds Pro

  24. If your pet is on anti inflammatory for arthritis but has previously been treated for liver inflammation , by taking Danamarin will this counteract the effects on the liver that the anti inflammatorys can cause ? ( my dog has stayed on Danamarin since 18 months ago being treated for Cholangiohepatitis. I also want to ask after being on Danamarin for so long is it best to break in half and give half per day or a whole one every second or third day ? Thank you

Leave a Comment