Why you need to ask your vet about pet drug interactions & side effects

Discuss potential medication side effects with your vet

In the middle of a busy veterinary practice, many veterinarians may overlook an opportunity to discuss the possibilities of drug interactions and pet medication side effects. For example, many commonly prescribed nonsteroidal anti-inflammatory medications (NSAIDs) can sometimes cause digestive upset and/or liver/kidney problems in some sensitive pets. Corticosteroids like Prednisone can cause similar problems in some pets, as well as predispose pets to diabetes with prolonged use.

While a topic of debate, these risks are increased if Prednisone and nonsteroidal anti-inflammatory drugs are used together.

While potentially lifesaving, antibiotics can also cause allergic reactions from digestive upset to skin irritation. Some pets are sensitive to topical flea and tick medications, and in my practice I always administer topical flea and tick medication on a separate day from heartworm preventative medication or vaccinations, in order to lessen the burden on a pet’s immune system.

Whenever multiple drugs are prescribed it is always important for pet owners to ask questions, because veterinarians not only prescribe pet medication but are also dispensing these medications in private practice.

Have pet health questions? For any medical concerns, we always recommend you consult your veterinarian. However, for non-emergency questions, you can contact Dr. Dym directly using our Ask the Vet form.

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1,898 Comments

  1. Trying to figure out the best times/combos with all the meds we are juggling. (Pepcid, prednisone bid, gabapentin bid, denamarin, atopica)
    Seems denamarin first thing on an empty stomach works. Wait 1 hr to give pepcid,prednisone, gabapentin. Then with dinner gabapentin and prednisone. Another 2hrs no food before atopica.

    Are they spread out enough? Anything I should do differently.

  2. can i use frontline on my 8lb morkie even though she is on phenobarbital?

  3. HI Brit. I dont know of any specific interactions of Bravecto with heartguard however best in my opinion to give on different days. I prefer one week apart.

  4. Phenobarbitol and Ivermectin do not have contraindications when used in same patient, however if your pet had seizures after heartguard, then you need to see your vet about another possible choice for heartworm prevention, as ivermectin, main ingredient in heartguard can on rare occasions worsen seizures in an epileptic patient.

  5. HI KAryn. Nexguard and prozac can be taken by same patient, however you should be under vet care and monitoring who is prescribing the medicine.

  6. There should be no problem using Galliprant and alprolezam in same patient, as long as prescribed and appropriately monitored by licensed vet

  7. HI Kara. Other than some sedation, there should not be a problem if your vet prescribed buprenorphine for the cystitis flareup if she is on keppra. I would have asked about gabapentin for cystitis relief which is also a seizure medication

  8. I dont see a problem using galliprant and apoquel together in same patient, if prescribed by your vet. I would give with food, however

  9. HI Suzon. I dont see a problem using apoquel and tramadol at same time in your pet

  10. HI Liz. I dont see problem using comfortis and levothryoxine in your pet if your vet has prescribed them.

  11. HI Dar. Sounds like you have the spacing out of these MANY drugs quite well, and sounds like a good plan in place. Check with your local vet for any adjustments, etc especially since a case like this needs close monitoring by local vet.

  12. HI Sharon. Re your morkie, I would check with your local vet if ok to use front line on pet with seizure disorder on phenobarbitol, as occasionally I have seen rare neurological reactions to front line. Check with your local vet

  13. Jennifer OropezaJune 5, 2018 at 4:42 pm

    Revolution and Denamarin for cat and dog with sensitivity toward Revolution?
    Also taking Omega 3 supplements for allergies and inflammation.
    The dog gets CBD oil also for inflammation only on ab as needed basis.

  14. Thank you for the response. Can denamarin be given with atopica. I don’t see any problems through research but wanted to check ?

  15. My dog was just prescribed Proin for incontinence issues. Unrelated to that issue, she hurt her back leg this morning and seems to have a pulled muscle and is limping. I don’t think it’s anything serious, but I’d like to give her Novox for the pain. Is there any problem with giving her Novox while she is taking Proin?

  16. I cannot for the life of me get flea medication on my 15 pound cat. Nor can I put a flea collar on her. She flips out. Has anyone given their cat Xanax to droz her out so I can get a sorresto collar on her? I have .25 xanax

  17. Hi Pat and thanks for your comment. For any medical concerns, we always recommend you consult your veterinarian. However, for non-emergency questions, you can contact Dr. Dym directly using our Ask the Vet form.
    ~ Abby, PetMeds Pro

  18. My 1 year old Basset Hound is scheduled for a spay surgery tomorrow. The vet instructed my husband to give her 20 mg of Prilosec tonight and again in the AM. He forgot that she also gets Apoquel twice a day. Is there a risk of giving both of these meds?

  19. Hi Kathy, and thank you for your question. For any medical concerns, we always recommend you consult your veterinarian. However, for non-emergency questions, you can contact Dr. Dym directly using our Ask the Vet form. We hope your furry friend is feeling better after her procedure!
    ~ Abby, PetMeds Pro

  20. My cat is on antibiotics. Is it safe to do his flea medication? He’s a 10yr old 15lb siamese

  21. Hi Rebecca and thank you for your question. For any medical concerns, we always recommend you consult your veterinarian. However, for non-emergency questions, you can contact Dr. Dym directly using our Ask the Vet form. We hope your cat is feeling better soon!
    ~ Abby, PetMeds Pro

  22. should I give my dog Nexgard if she is already taking Apoquel?
    She is a 65 pound pit bull who is allergic to everything.

  23. Hi Heidi, and thank you for your question. For any medical concerns, we always recommend you consult your veterinarian. However, for non-emergency questions, you can contact Dr. Dym directly using our Ask the Vet form.
    ~ Abby, PetMeds Pro

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