What to do when pet’s flea medication stops working

 To eliminate a flea infestation, it takes patience treating your pet and your environment.

All too often, a pet owner will come in and share their experience in which he or she regularly applies topical flea prevention, yet is frustrated that after several treatments they are still seeing fleas. There are several plausible explanations for persistent flea infestations which may have nothing to do with lack of efficacy of these products.

Apply flea medication properly for maximum effectiveness

First, I ensure the pet owner is correctly applying the flea medication to his or her pet. It is important to completely part the hair and apply the product directly to the skin so that proper skin and hair follicle distribution can occur. This is something that can be somewhat of a challenge for thick haired pets; however, the pet medication will not work properly if only the hair follicles receive the medication – it must be applied to the skin. Next, it’s important to properly follow product label directions, which may vary depending on the size of your pet. For instance, for large dogs, Advantage II requires the product to be applied on multiple spots down the pet’s back.

While it is tempting to try and save money by using only portions of products labeled for larger pets on smaller animals, it’s a process such as this that can lead to product inefficiency.

Ensure your home and yard are treated 

Another reason for products not working is by not treating your home and yard, where in some cases 80% of the flea life cycle may occur. Read how to control fleas indoors and outdoors.

In cases of heavy flea infestations, some home products such as Advantage Carpet and Upholstery Spray kills fleas and ticks quickly and continues to kill fleas for two weeks. In spite of recent discussion in the veterinary literature, the development of widespread flea resistance is still not believed to be a major factor to clients still finding fleas on their pets.

Consider switching to oral flea medications

The newer oral flea medications are becoming very popular and with good reason — they’re even more effective than topical treatments at killing adult fleas and keeping your pet flea-free. Plus, with an oral flea treatment, you eliminate the mess of topical flea treatments and the worry about whether you’ve applied the product properly.

Have you been battling a flea infestation in your home? What are some of the ways in which you have been trying to get rid of them? 

Have pet health questions? For any medical concerns, we always recommend you consult your veterinarian. However, for non-emergency questions, you can contact Dr. Dym directly using our Ask the Vet form.

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  1. I have a 16 yo indoor female cat who is infested again with fleas. I’ve been using Bio every month for 3 months washed everything possible flea combed bathed in Dawn almost weekly and treated indoor enviornment plus vacuumed. No good results. Cannot kill cycles or mature fleas!! My cat is overweight and may be diabetic. I’m afraid vet’s meds may be too toxic. Beside myself…not sure what to do…this cat is my life and don’t want to lose her!!

  2. Hi Carole and thank you for your question. For any medical concerns, we always recommend you consult your veterinarian. However, for non-emergency questions, you can contact Dr. Dym directly using our Ask the Vet form. We hope your kitty is flea-free soon!
    ~ Abby, PetMeds Pro

  3. I have a10 month old Peekapoo puppy. I applied Advantix 2 which worked great on my previous dog. It worked great this time for about 2 weeks and now she is miserable with fleas. What can I do since the Advantix is a monthly treatment?? I bathed her in Dawn but that’s only good for a couple of days and I don’t want to dry out her skin by washing too often. Please help!!

  4. Hi Joy. We’re sorry to hear your pup is troubled by fleas. Here’s what Bayer has to say about K9 Advantix:

    “Although K9 Advantix® II kills fleas on your dog, there may still be fleas in your dog’s environment that have since jumped on after treatment. Luckily, with K9 Advantix® II, new fleas are killed within 2 hours with protection against further infestation for at least 4 weeks. As fleas die they are no longer able to stay hidden against your dog’s skin, and therefore you may also be seeing dying fleas coming to the surface of your dog’s fur coat.”

    We recommend treating the environment with a room spray or fogger. In the meantime, ask your vet about using an oral product such as Capstar which will immediately kill any remaining adult fleas, although the effect will only last for 24 hours.
    ~ Abby, PetMeds Pro

  5. I have a nearly seven year old cat named Genevieve. We got her from the shelter over 8 months ago and when we took her in for her first check up she had some hot spots on her skin. Vet didn’t see it as much of a problem, but we got recommended that we keep her on flea treatment in case it was a flea allergy and to change her food to grain free in case it was a food allergy. She is indoor only.
    For the past two months we have found fleas on her and have tried changing her flea meds (she was on Petarmor, then switched to Frontline, now switched to Advantage 2). Each time the fleas disappear for a while, i strip the covers off our couches as well as bed, spray advantage indoor home spray on nearly every surface, and yet still the fleas come back 5-6 days later. We have been careful to wait the full 7-30 days as the instructions on the box specify (Advantage says for infestations, a flea treatment every 7 days can be helpful, while Petarmor and Frontline said 30 days minimum between dosages). We gave her a flea bath between switching from Petarmor and Frontline, and that worked a while as well. Every two days I comb through her fur with a flea comb and drown the live fleas in a liquid dish detergent/water mix. Still, fleas.
    This case of fleas has aggravated her skin so much that she has many hot spots, she itches herself until she bleeds (we have since put a cone on her to prevent such damaging scratching and biting), and she has been losing fur. We took her to the vet before she started losing fur and the vet recommended the advantage spray for the home and advantage 2 flea treatment for cats over 9 lbs.
    Is there anything else further that I could be doing? Not sure how my apartment complex would respond to us flea bombing the place, but if need be I could do so.

  6. You have to be careful with oral flea and tick preventatives though-most oral products work by running through the bloodstream and ultimately it can lead to a dog needing to be bit by a flea or tick in order for it to die. This can lead to infections/disease transfer even if the flea/tick does die in the end (long story short: protects your home from fleas and ticks more than your pet). I typically use a collar (like Seresto) to keep my dog protected. You just have to be careful if the dog is going to be receiving baths/swimming a lot, as this reduces the lifespan of the collar.

    I have yet to see a tick on my dog when he has been wearing his Seresto collar, but I have picked many from pups on oral treatments like Nexgard.

    For a frame of reference, I live up in MN and go camping/hiking a lot where I can easily be picking 20-30 ticks off of myself in a day, and my dog is staying tick free with his collar (with just the oral medication, he would usually be crawling with them when we got back to our campsite).

  7. After 2 weeks my dogs fleas came back after using Frontline plus

  8. Kimberly CampigliaFebruary 9, 2019 at 1:18 pm

    Carole Motsett- My vet told me not wash my pet in dawn soap as the soap will wash off the topical flea medication. Use a soap free shampoo.

  9. I have tried K-9 Advantage, Frontline Gold and now she is on Trifexis – NOTHING WORKS FOR THE FLEAS!!!
    Is there anything out there that truly does what the manufacturer claims it does???

  10. Hi Suzan. I have had good results with the Seresto collar. It lasts for 8 months

  11. Fleas are from the devil. Despite regular treatment with Effitix, they have taken over our pets and our lives, why oh why do these products not work??

  12. I just rescue a pit mix she is 11 months old I bought k9 Advantix ii she is an inside dog but it seems that when I walk her she picks up fleas and it seems K9 Advantix ii is not doing the job, oh and by the way I also spray the carpet and furniture because I hate when I feel the fleas bite me.

  13. I also tried all of the above remedies and comments. Finally called Terminix. That did the job along with vacuuming everything everyday for 3 weeks. That was last September. All good so far

  14. Using Advantage for my cat for 4 months and don’t think it’s been working

  15. With 3 outdoor cats and a dog, I have found the only way to get rid of them in the winter (or any time) is diatomaceous earth. Make sure you get the non-toxic type. Put it on your rugs, and make sure it gets deep into the nap. It is messy but not destructive. You’ll need to wipe down hardwood floors and furniture for several days. Let it sit in the rugs for a day, then vacuum. You will need to vacuum a few times to get most of it. Comb a bit into your pet’s hair down to the skin.

    I’ve done this twice, and I’m thinking of doing it this year. Let me be clear: this is a very messy procedure. However, it has been the only complete success I’ve found. Let me also be clear that it is non-toxic to both people and animals (except, of course, fleas). It has the texture of flour, but it is like a microscopic razor blade that slices through the shell of the flea, causing them to dehydrate. For about a week or so, you’ll need to mop up white footprints from animals and humans, but it will be worth it. However, if you just can’t tolerate a mess, it’s not for you.

  16. I have 2 indoor dogs that have free access to outside. I’ve tried advantix, frontline, sorento collars, several features shampoos, flea spray, and affix. I’ve use flea granules in the yard, flea carpet sprays and powders, and bombed the house and they still have fleas. I think we have zombie fleas! I just took in a foster dog and he is treated with effitix at the shelter and was flea free and now he has them too. He’s only been here 4 days.

  17. I have a 7.5 Chihuahua that revolution only worked 2 weeks ban I give her a 2nd does but use effitix

  18. My bf has outside dogs that have fleas. We’ve been together for about 2 years and we live separately.

    I have 2 indoor cats that I use revolution on. I ran out of it in Dec 2019, and completely forgot about applying it until I noticed that my cats were infested in March 2020. Since then I have ordered advantage multi and applied it every month, and still I am having problems getting the fleas off my cats. I’m pretty sure they are migrating from his house to mine; and I have told him that he needs to take his pets to the vet or at least treat his home.

    Recently he fogged his house, and washed the dogs. But I don’t think that will be enough to rid his home/ dogs of fleas. I am so frustrated with this whole situation that I don’t know what to do outside of buying medication and treating his dogs myself (which I should not have to do)

    If anyone has been in and found a resolution for a situation similar to this, please advise me!!

  19. I agree about the dimithicus earth as stated above. But it must be food grade only and if inhaled when putting it down it can really be bad for pets. I always keep my 12 cats on the outdoor patio and open the window s and turn on fan when using it. Then let them back in 20 minutes later and treat my indoor sunroom / catio and repeat. I’ve tried bombing w advantage 2 but a week later saw thing with fleas, I’m in the south a d humidity is a beast fleas love humidity—investing in a few humidifier is another thing I’m looking into. Zombie Fleas exist here and Ive tried almost everything RX and regular senior kitties can’t use and shouldn’t use anything but frontline or natural dimithicus earth as a treatment, per my holistic vet. Chestrian was also recommended fir my 19 year old but honestly nothing really works that well, when I lived in CA no problem w fleas at all but here in the south it’s insane and fleas are absolutely immune it seems to most things. Black and brown fleas…hate them!! May have to move back to the west coast but for now I’m going to keep trying other things. Spraying them with apple cider vinegar before they go out with me supervised in the garden — helps repeal fleas but isn’t a solid protection.

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