K9 Advantix: A simple way to protect your dog from fleas & ticks

K9 Advantix II is still effective even after washing and bathing.

K9 Advantix II is among the most commonly used monthly topical medications used for controlling fleas, ticks and mosquitoes on dogs. As the weather continues to heat up and water activities increase, one of the additional benefits is that K9 Advantix II is still effective even after washing and bathing. In addition, K9 Advantix II not only quickly kills mature and immature fleas and ticks, but also repels these parasites from biting.

K9 Advantix kills and repels fleas and ticks

Available in 3, 6, or 12-packs, K9 Advantix II comes in convenient dosing packaging for dogs up to 10 pounds, dogs from 11-20 pounds, dogs from 21-55 pounds, and dogs over 55 pounds.

If your pet is in between weight ranges, you can always start with the lower dose of K9 Advantix II; however, if effective pest control is not seen, then giving the higher dose is certainly safe in most pets. It is not necessary to separate dogs after dosing them topically with this product; however, if dogs are actively playful and/or licking one another, it may be best to have them apart for a few hours, until the product has had a chance to dry.

Previously, it was recommended not to purchase this product if an animal guardian also had cats due to their sensitivity to the permethrin insecticide in this product. That labeling has now changed and it is ok to use in households with cats–as long as pet owners wait until the product is completely dry on one’s dog before exposing them to household cats.

Side effects are rare, but may include (in sensitive pets):

  • Contact irritation/allergy causing hair loss at site of application
  • Digestive upset
  • Neurological reactions such as seizures (rare cases)

If these symptoms should should occur, consider speaking with your veterinarian about changing to an oral flea preventative such as NexGard or Trifexis. For more information on these newer flea control products, read our article on the Benefits of Oral Flea Medications.

Learn the benefits of oral flea treatments

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  1. I absolutely concur regarding over the counter or non name . brand flea and tick topical products. My Mother purchased (by mail order) some kind of alternate product-and now both dogs are a mess of fleas and ‘itchies\. I never had a problem (even in Virginia, which seems to be the flea capitol of the world) when I was using the name brand products.
    Listen up people before you have dogs in agony like mine!

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  3. I agree with Nina. You think you are saving on generic or cheap dollar store brands but they either never work, halfway work or cause bad reactions. I am a vet tech and I only use and recommend K9 Advantix to patients. Even though my boss hates that I do it; I always tell patients to search for the best deal online. You can save a lot with all the competition online.

  4. Hi, I have a question, is it safe to use a topical flea and tick medicine (advantage) with an additional store bought flea collar? I am concerned that the dog may have adverse reactions with mixing flea and tick meds.
    My husband just applied a topical med. (advantage) last week to our 60 lb. Catahoola Leopard dog Koda. Today I found my dog with a flea collar around his neck. Any thoughts or suggestions would be appreciated.

  5. Dr. Michael Dym, VMD veterinarianOctober 23, 2010 at 12:09 pm

    I would not use both as too much pesticide. Stick with advantage and treat home for fleas. Can use oral capstar and/or oral program if needed from 1800petmeds if heavy infestation

  6. The label on Advantix says not to touch your dog after it has been applied….but how long do I have to wait before I can hold and pet her? She is a little chihuahua that cannot sleep unless she’s under your blankets…so I want to know when it’s safe for her to be in my bed. Thanks!

  7. I bought k9 advantix and it says not get on skin but how long before I can touch my dog after applied?

  8. Dr. Michael Dym, VMD veterinarianMarch 13, 2011 at 11:30 am

    As soon as the product dries within a few hours you should be fine

  9. I just purchased the new Advantix II, I have two large dogs and i have always used Advantix on them. After i applied this new product i noticed one of my dogs started acting very strange, he started panting and acting very irritated. He keeps moving around and wont lay still. My other dog seems to be fine, and she is acting normal. Im not sure what is going on or what to do with him. Like i said i have always used Advantix and this has never happened before.

  10. Dr. Michael Dym, VMD veterinarianApril 7, 2011 at 9:34 pm

    There is extra ingredient in the advantix II that may be causing the reaction in your pet. Every animal is a unique individual. I would change back to advantix or go to front line

  11. I just picked up my dog’s next heart worm pills and was told by the folks there that my vet does not recommend flea and tick collars. Then I saw all these horrors stories posted online about dogs getting really sick or dying from Hartz collars. I just took it off my 65lb lab puppy. How long should I wait to put the k9 advantix on him and is there anything else I should do? He has worn the collar for about two weeks..we did notice he doesn’t eat like he was eating before…and drinks a lot more..but then it has been really hot here lately…..

  12. I have been using advantix on my pomeranian since she was a pup with no problem. Now the last two months she has been having fleas. I just put drops on her two weeks ago and she had enough fleas that the groomer had to give her a flea bath. I am thinking of switching to frontline plus to see if she could be getting immune to the advantix. How long will I have to wait till it is safe to put the frontline plus on her. She still has fleas. I also bought capstar. When is it safe to give her any more meds?

  13. Dr. Michael Dym, VMD veterinarianJune 11, 2011 at 3:16 pm

    You can wait 2 weeks after last topical flea application to change to different brand. Remember to also treat the home environment as well which is where much of flea life cycle occurs.

  14. I applied K9 Advantix II 10 pounds and under to my dog. My daughter did not know I had already done it and I discovered that she put some on him later that same day. So he was double dosed. Do I need to do anything?

  15. Dr. Michael Dym, VMD veterinarianAugust 1, 2011 at 11:49 am

    I would try and wash dog however product is supposedly water proof. Most likely your dog will be fine. I would just monitor and observe for any lethargy or digestive upset, etc

  16. I applied K9 Advantix to our Jack Russell 3 weeks ago and I think I have seen a flea or 2 in the last 2 days. Is it OK to reapply even though a full month has not passed? She is a small 12 lb dog. Also, it is hard to really separate her fur completely when applying it because her fur is so short. The flea med. does get on her fur. Does that matter and could that effect the absorption of the med.?

  17. Dr. Michael Dym, VMD veterinarianAugust 6, 2011 at 12:41 pm

    Not applying the product completely on the skin can affect absorption and sometimes efficacy. I have had clients use the product a week early so go ahead and reapply. Also make sure to treat home environment of pet where much of flea life cycle occurs.

  18. Pingback:   K9 Advantix II four Pk Blue Dog Over 55 lbs.|Cheap Pet Supplies

  19. Hello-

    How long has Advantix II been used on dogs? Is there any research on the safety of the product?


  20. Dr. Michael Dym, VMD veterinarianApril 9, 2012 at 8:27 pm

    Advantix II has been on the market a few years. I would check with the Bayer company who manufacturs it on safety studies.

  21. Hi,
    I have a dog and two cats. Earlier today I applied K9 Advantix to the dog and wonder how long I have to keep her from her feline brothers? I worry they will attempt to lick her spot. Is it safe to put a little cotton tshirt on her for 24 hours so that the cats can’t get to her?

    Thank you!

  22. Dr. Michael Dym, VMD veterinarianMay 6, 2012 at 1:45 pm

    A cotton teashirt would be fine for 24 hours to prevent cats from contacting the product.

  23. I use K9Advantix on my dogs. My lab weighs 133 lbs. After 2 weeks, he has fleas again. I have a dachshund who weighs 10 lbs., who I also use the K9Advantix on. When my lab gets fleas, they go onto her too after 2 weeks. Why doesn’t this stuff effectively eliminate the fleas for the whole month? I only started using the K9Advantix because it was the only one with tick repeallant, but I took two ticks off of him and he even got lyme’s disease. I feel like I am wasting my money.

  24. Dr. Michael Dym, VMD veterinarianJuly 20, 2012 at 5:27 pm

    Sometimes during heavy infestations, the product needs to be applied more frequently. Also could try another product such as certifect

  25. I was given advantage 20 for11-20 lbs. Can I use less for my 5ish pound chihuahua and more for my 85 lb retriever?

  26. Dr. Michael Dym, VMD veterinarianJuly 21, 2012 at 2:57 pm

    I usually follow the labelled recommendations for these products.

  27. I just started my dealing with resolving my flea problems today (i have had an issue for about 2 weeks) before I put the advantix on my 20lb dog what can I use to help her with her discomfort (itching from bites) then what can I do to help her once i start the advantix?

  28. Dr. Michael Dym, VMD veterinarianAugust 16, 2012 at 2:40 pm

    TRy oral benadryl at dose of 1 mg per pound twice daily and add fatty acid like missing link to meals from 1800petmeds which may help long term.

  29. How long after applying k9 advavntix II can my animals be allowed on the furniture

  30. Dr. Michael Dym, VMD veterinarianSeptember 16, 2012 at 8:39 pm

    Usually after 2 hours and/or when it is dry.

  31. I gave my dog his last dose of frontline plus one 8 days ago and noticed it wasn’t working anymore. I have orderd the K9 advantix….how long do I have to wait before giving him the new stuff. The Capstar doesn’t work for very long and my pup is miserable. I hate to think he has to wait 22 more days before I can give him the new meds.

  32. Dr. Michael Dym, VMD veterinarianNovember 5, 2012 at 6:52 pm

    I would wait 2 weeks from last dose of front line and then try the advantix.

  33. I bought Advantix II for my dog, but I bought the 55 lbs + dose and weighed her at 50 lbs. Is it safe to give her the 55 + dose or should I return it and buy the lower dose?

  34. Dr. Michael Dym, VMD veterinarianNovember 11, 2012 at 4:44 pm

    The higher dose should be fine.

  35. I have two small dogs, which I bought K9 Advantix II for (10-20 lb dosage). I have a large lab who weighs around 90 lbs. Is it safe to give the large dog 3 doses of the small dogs’ meds?

  36. Dr. Michael Dym, VMD veterinarianNovember 20, 2012 at 8:41 pm

    I only recommend using the recommended dose in the packaging for this product.

  37. I but the K9 Advantix II on my dog last night. She stays at my nephew’s in the morning (doggie day care). He has 2 yound children. It is safe for her to be over there with the children, or is the product dry enough for her to be around the kids?

  38. Dr. Michael Dym, VMD veterinarianMay 16, 2013 at 9:34 pm

    once producct is dry it should be safe and fine.

  39. I used K9 advantrix II for medium dog two weeks ago, it seemed to work for a while and now he’s loaded down with them again. What can I do?

  40. Dr. Michael Dym, VMD veterinarianJune 24, 2013 at 11:33 am

    Try oral comfortis from 1800petmeds and make sure you treat home.

  41. my dog has seizures and can’t have the oral kind. I went ahead and bathed him today and set of foggers in my house again and am washing everything. I wrote I put advantrix II on him two weeks ago but I realized that was wrong. I put it on him June 14, it only lasted a week. Can you recommend what I can do now?

  42. Dr. Michael Dym, VMD veterinarianJune 25, 2013 at 10:31 pm

    Try natural flea regimens such as http://www.wondercide.com or http://www.cedarcide.com

  43. we gave our dog the regular dose to get rid of fleas from her vet. am i right in brushing her after 1 week 1/2 she still has fleas. my husband says i shouldn’t brush her. who is right ? should i continue and leave them on her or brush her and continue to remove at least 7 fleas a day from her?

  44. Dr. Michael Dym, VMD veterinarianJuly 8, 2013 at 11:56 pm

    Brushing is fine. I would just consider using additional flea meds like comfortis from 1800petmeds.

  45. I just gave my dog his first foe and tick dose of Advantix II

    1) How long does it typically take to dry enough that I can hug and kiss him again?

    2) I was planning on giving him his bath next week. Will this weaken the affects of the Advantix?

  46. Dr. Michael Dym, VMD veterinarianAugust 11, 2013 at 9:40 am

    Once product dries within a few hours, should be able to kiss him. Bathing one week from now is not a problem.

  47. I agree with nina, when it comes to flea and tick control… you get what you pay for. I have only had luck with Advanitx products. I have not tried K9 Advantix II yet. I’ve always just used K9 Advantix because it works. Why change some that works!?

    BudgetPetCare.com is cheaper and you get free ones when you order. OTC items have been killing dogs or making dogs sick. I have not had any problems with this brand.

  48. Dr. Michael Dym, VMD veterinarianAugust 21, 2013 at 12:17 am

    Thanks for sharing.

  49. Simply desire to say your article is as astonishing. The clearness in your post is
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  50. Dr. Michael Dym, VMD veterinarianNovember 25, 2013 at 9:55 am

    THank you for your kind complements on our blog services.

  51. I am confused, the homeopathic vets say NO pesticides, unless the flea/tick infestation is extreme.

    The specialist that sees my 9.5 pound poodle says to do Advantix II on the 1st of the month, Revolution on the 15th, 2 pesticides per month?

    This sounds like too much, so I am going to continue monthly Advantix II, occasional Amitraz collars and Heartguard (which I give every 6 weeks) annual testing.

    Brewers yeast and garlic tabs, BugGone spray, frequent bathing. Frequent checking and avoidance of tall grass/brush, NO woods.

    I lost one dog to Lyme (kidney damage) years ago.
    I also had 2 test positive but never had any symptoms.
    The ticks are moderate too bad in my area.

    What do you think of my plan?

  52. Dr. Michael Dym, VMD veterinarianJanuary 9, 2014 at 1:52 am

    Sounds like a few too many pesticides for my liking. Stick with revolution and perhaps a natural tick preventative like http://www.wondercide.com

  53. Thanks, Dr Dym, I have ordered the Wondercide and will use it in conjunction with Advantix II and the other natural remedies I mentioned.
    The homeopathic vets advise to stay away from Revolution, so I’ll continue with the Hearguard every 6 weeks (3 seasons) and annual testing.

  54. Dr. Michael Dym, VMD veterinarianJanuary 14, 2014 at 6:15 pm

    You are very welcome…. Keep up the good work

  55. Is it normal for my 10lb yorkie to scurry around the day I apply the the K9 advantix II? He typically does this only on the day of application. He seems restless and can’t stay still too long, hides and rushes from place to place.

  56. Dr. Michael Dym, VMD veterinarianJune 29, 2014 at 4:18 pm

    This is not normal and is a reaction to the topical advantix. I would NOT continue to use it, as I would be concerned about long term effects on the body. Consider different topical such as revolution or changing to oral medicine.

  57. I put k9 advantix on my dog on Wednesday night around 9:30 I gave my dog a bath this morning (Saturday around 10:30). I’m worried I bathed him too early is that true? And if so is the medicine going to be in effective now?

    Any help would be great!

  58. Dr. Michael Dym, VMD veterinarianJuly 8, 2014 at 9:37 pm

    Should not be a problem. The advantix should still be effective

  59. I have two German Shepherd Mix dogs. One is 56 lbs, one is 50 lbs. I have a few questions.
    1) Should I dose them both at the up to 55lbs, or the 56 lb dog at the 55+ lbs dose or…?
    2) I just moved to Florida from MN and have never dealt with fleas before. I bathed them in a flea and tick shampoo about two hours before applying K9 Advantix II. Is it still effective? I have picked about 20 fleas off of each them today, which is almost a week after application. When can I apply another dose?
    3) How do I treat the home/yard? I know this is an important step, yet I haven’t heard a safe solution.

  60. Dr. Michael Dym, VMD veterinarianAugust 6, 2014 at 7:59 pm

    There are yard and kennel sprays you can buy from local hardware stores. Some vets do carry yard sprays as well. You could also speak to gardner or exterminator as well for expert treatment. As for reapplying the advantix, I would wait a few more days, and then reapply. I usually dont recommend bathing 2 days before or after application. As for dosing, I think the 33 pound dose is fine for both dogs.

  61. I have tried both frontline and advantix on my 70lb lab pit mix. They work great for fleas but they are making him sick. He has severe upset stomach and pukes alot. We have since stopped and the symptoms quit. Are their any other flea meds we can try? We are currently bathing him weekly and put cedar chips out to help keep fleas away but not working the same.

  62. Dr. Michael Dym, VMD veterinarianSeptember 3, 2014 at 5:05 pm

    Maybe try the natural product at http://www.wondercide.com or you could try oral comfortis from 1800petmeds.

  63. I used K9 Advantix on both of my dogs 8/29/14 according to their weight. Both were again infested with fleas one week later. Today, nine days later, 9/7/14, I put Sergeant’s Gold Flea & Tick collars on both of them 8 hours ago and they both seem to be fine, sleeping comfortably and no longer itching like crazy so I took the collars off. When can I put the collars back on and leave them on? Thank you.

  64. Dr. Michael Dym, VMD veterinarianSeptember 8, 2014 at 3:31 pm

    You can put collars back on at any time

  65. Thank you so much! My dogs will sleep comfortably tonight and so will I! You go above and beyond your call of duty; I wish you were a vet in my area, Concord, California; we would love to have you here if you ever want to relocate!

  66. Dr. Michael Dym, VMD veterinarianSeptember 9, 2014 at 6:01 pm

    Thanks for your kind compliments

  67. Pingback: Can K9 Advantix Make My Dog Sick | Doggy Diarrhea

  68. I have 2 shit-zu mixes weighing 17 and 20 pounds. Can I give both dogs the k9 advantix for 21-55 pound dogs?

  69. I am a nursing mother and got this product on my hands. I washed them shortly after. Is it safe to continue to nurse my baby? I am worried this product is absorbed into my skin

  70. Brit, This is nasty stuff! Call your local hospital emergency room and ask for the advice nurse if Dr. Dym doesn’t get back to you soon. He usually relies within 12 to 24 hours, but your situation is somewhat urgent (in my mind.) You are probably fine, but why risk it? Good luck to you and your little one!

  71. Hi, I went online and bought advantix for dogs ten pounds and under I have a shih tzu who is 15 pounds. Will it work fine or should I apply two of the viles?

  72. 3 days ago we found our mini schnauzer (25lbs.) had a few fleas crawling on him. He had no flea bites that we could see. We bathed him, and applied K9 Advantix II for 21-55 lb. Dogs. 3 days have passed. He has about 5 flea bites that we can see, and whenever we check him we are able to see a couple of fleas. 1) at what point should we stop seeing fleas? 2) can we apply a second dose of advantix, and how soon? 3) Since I am seeing 1-2 fleas at a time would that be indicative of a flea problem in the house? Thanks in adavnce!!

  73. Dr. Michael Dym, VMD veterinarianDecember 25, 2014 at 10:04 am

    I have found this product not always as effective as it used to be. I would consider using oral comfortis from 1800petmeds, and I would certainly recommend treating the home.

  74. My dogs neck is irritated and is now losing hair after putting K9 flea medicine on it. What should I do?

  75. I have a Schnoodle and have been using K9 Advantix Il for years with no issue. Tonight when I applied the treatment almost immediately a deep burgundy/dark purple stain appeared on her fur above her tail on her back. This happened once before last year and eventually it faded away but I was wondering if anyone has heard of this issue. She seems fine and like I said I’ve always used the same K9 Advantix ll. The stain appeared in only one spot where the treatment was applied but not on the other areas on her back where it was also applied. Strange.

  76. Sounds like topical reaction to advantix. I would recommend switching to alternative product like topical revolution or possibly oral sentinel

  77. I give my dog advantix11 and he does well on it do I still have to give him a heart worm medicine because he a seizure 2 days after giving him sentinel

  78. I would discuss these concerns with your local veterinarian as the decision to use heartworm medicines in a dog prone to seizures will be based on the actual risk in your area. There are also other options for flea and/or heartworm medicine as well such as prescription topical revolution

  79. I have two shih tzu maltese mix dogs.I applied the k9 advantix on both of them one of my dogs the next day was panting barking scurry around in circles laying on her back moving around. She seems uncomfortable. This is not like her at all. I’ve read other posts about their dogs doing the same thing. How long will thisn reaction last? She is 16 pounds and 14 years old

  80. Typically the reaction will only last a day or two, however you can try washing product off, if caught within a few days. Otherwise, if neurological signs persist, you will need to see your local vet for exam and evaluation.

  81. Hi, apologies if this question has been answered already but I was just wondering how long the product took to dry? I’m really interested in trying a flea prevention product but with a household that includes cats I’m just wondering how long they should be kept apart after applying K9 Advantix?

  82. They usually dry within 6 to 12 hours.

  83. Hello. I gave my dog a dose of K9 advantage II and she was very restless at night. She typically sleeps well, but it as very difficult for her to get comfortable. Is this a possible side-effect?

  84. It is possible to have rare neurological excitation and side effect. If sign persists, see your vet. May want to wash product off as well

  85. To my shame I ordered revelution for my dogs this time. I applied it on July 8th, 10 days ago. I just found 3 ticks on my 25-30 lbs Bassett Hound. I had also ordered k9 advantix by accident. Its what i normally order. Is it too soon to apply advantix? I’ve got an 7 lbs yorkie that revelution is working fine on but he can’t get into half the mess this Hound can.

  86. I usually wait at least 2 weeks before applying another topical flea and/or tick product on an animal

  87. I have three dogs who have had Frontline monthly and no fleas ever. Until now. I applied Frontline on august 2nd. Today I found fleas on all three dogs. We gave them baths using a natural flea shampoo (peppermint and clove oil) and sprayed them with Ovitrol and began treating the house with Siphotrol. I Bought K9 Advantix II for them. When can I put it on them? Also, our mini schnauzer/poodle mix had a very bad reaction to Vectra last year. Do I need to worry about using the Advantix on him?

  88. Every flea product is different, so that a pet that reacted to Vectra should likely not react to advantx II, although occasionally pets are sensitive to any topical pesticides for flea control. I think you should be ok to apply another product like advantix now. You also may want to treat your home environment as well for fleas with products like knockout.

  89. Hi, recently I got a 7 pounds poodle but she came last year during winter time so no flea problems, now she got fleas and is a nightmare, I applied Advantix a month ago and now I applied again but late that day I sprayed water with coconut oil on her to brush her ( I love the smell of coconut and someone told me it helps with her fur) but I totally forgot about the Advantix, I wonder if that will take the effect of this medicine.

    Thanks for having this wonderful site.

  90. I dont think the coconut oil will cause a problem with the advantix if applied one month ago. She may need additional applications of the advantix for continued effective flea prevention

  91. I need help! I applied a flea serum to my small dog and now she is losing her hair she has sores from scratching constantly. I was wondering what I could do to help with this. Would an oatmeal bath help or a very mild shampoo for the itchiness?

  92. HI Misty. Sorry to hear of this reaction. You could try a dose of childrens benadryl at dose of 1/4 to 1/2 childrens dose twice daily which may help itching as well as the oatmeal baths. However may need vet exam and evaluation to help sort out if antibiotic or stronger anti itch medication needed

  93. Hi there I have been treating my dog with advantix II (150 lbs) for some time now and he was last treated on Aug 15th and has just come into contact with fleas he is covered we noticed Monday when coming from our nasty rental home. I have treated him again yesterday (Tuesday ) and it is just over 24 hours. I have found loads of dead ones but he is still licking and chewing some will this stop or shall I treat again ? I have the spray to do our home as well but just haven’t gotten the time to do so with my work schedule and having to be out of the home for at least 2 hours afterwards. Am I just over acting 🙂 and they will all die in the next 12 hours maybe ? Thank you!

  94. They should die within 24 hours. If itching persists, can try benadryl at dose of 1 mg per pound twice daily; also make sure you treat home, as much of flea life cycle occurs in home. If itching persists, I would not immediately reapply the product. you may want to schedule vet exam to see if stronger anti itch meds needed and/or antibiotic therapy needed.

  95. Can I use advantix ii along with diatomaceous powder applied topically on my 30lb. Husky pup?

  96. HI Tina. I personally would use one or the other. Even if natural, the body still has to process any residues that are absorbed through the skin or licked off inadvertently. If Advantix not working for you, you can choose another prescription pesticide flea product, OR if you prefer to go natural, then using diatomaceous earth fine to use. I would not use both at same time in my opinion.

  97. I have 2 puppies that are 12 weeks old. So they are old enough for topical flea treatment but they only weigh 2 and a half pounds. Is it safe to put k9 advantix on them.

  98. Hi Crystal. They are old enough for flea products to be applied, however I prefer topical revolution to this product which has convenient dosing for pets below 5 pounds. You will need written script from your vet

  99. Can i use coconut oil on dog’s skin after treating with Advantix II?

  100. HI Paula. I dont see a problem using coconut oil on dog’s skin after treating with advantix, although I would wait 2 to 3 days after applying the advantix to use it topically. Also consider oral coconut oil to the food at dose of 1/4 teaspoon per 10 pounds of body weight twice daily mixed in food

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